Serum Adiponectin Levels are Inversely Correlated with Insulin Resistance in Obese Men with Type 2 Diabetes


avatar Mojtaba Izadi 1 , avatar Mohammad Taghi Goodarzi 2 , * , avatar Hamidreza Samari Khalaj 1 , avatar Davood Khorshidi 1 , avatar Hossein Doali 1

Islamic Azad University, Saveh Branch, Saveh, IR Iran
Research Center for Molecular Medicine Hamadan University of Medical Sciences, Hamadan, IR Iran

how to cite: Izadi M, Goodarzi M T, Samari Khalaj H , Khorshidi D, Doali H. Serum Adiponectin Levels are Inversely Correlated with Insulin Resistance in Obese Men with Type 2 Diabetes. Int J Endocrinol Metab. 2011;9(1):e94649.


Background: Obesity is associated with several chronic conditions such as atherosclerosis and hypertension. All of these are risk factors that contribute to metabolic syndrome, which in turn can lead to cardiovascular disease and type 2 diabetes.
Objectives: In this study, we aimed to show the relationship between insulin resistance and serum levels of adiponectin, an anti-inflammatory adipokine, in obese men with type 2 diabetes.
Patients and Methods: Serum concentrations of adiponectin, insulin, and glucose were measured in 48 obese men (BMI > 29) with type 2 diabetes, aged 37 to 53 years and having a body weight of 80 to 100 kg. Insulin resistance index values were calculated using measurements of fasting glucose and insulin levels. Using Pearson’s correlation test, the relationship of serum adiponectin concentration with insulin resistance, serum glucose, and insulin levels, was determined.
Results: The results showed a significant inverse relationship between adiponectin concentration and insulin resistance in type 2 diabetic patients (p = 0.000, r = -0.59). In addition, a significant relationship was observed between fasting glucose and adiponectin levels (p = 0.005). The relationship between insulin and adiponectin levels was not significant (p = 0.196).
Conclusions: Our findings indicate that the concentration of adiponectin, an anti-inflammatory and antidiabetic marker, is a precise insulin resistance predictor in obese patients with type 2 diabetes.


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