Leksell Gamma Knife : An Effective Non Invasive Treatment for Rare Case of Nelson’s Syndrome


avatar faheem arshad 1 , * , avatar bashir ahmad Laway 1 , avatar Manzoor Ahmad bhat 1 , avatar hakim Irfan Showkat 1 , avatar suman Kotwal 1 , avatar shahnaz Ahmad Mir 1

Sher-i-Kashmir Institute of Medical Sciences (SKIMS) Soura, Resident Scholar Endocrinology, Srinagar, India

how to cite: arshad F, Laway B A, bhat M A, Showkat H I, Kotwal S, et al. Leksell Gamma Knife : An Effective Non Invasive Treatment for Rare Case of Nelson’s Syndrome. Int J Endocrinol Metab. 2013;11(3):e94659. https://doi.org/10.5812/ijem.10225.


Nelson’s syndrome nowadays a rare entity results from an adrenocorticotropin (ACTH)–secreting pituitary adenoma in patients with refractory Cushing's disease after a therapeutic bilateral adrenal gland removal. We report a case of 25 year old female with cushing’s disease who was initially managed with medical treatment, but in view of severe persistent hyper cortisol state was subjected to bilateral adrenalectomy following which she developed Nelson’s syndrome after a gap of six years, which was difficult to diagnose because of limited investigations available. Patient was managed with stereotactic radiosurgery (gamma knife surgery).


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