Evaluation of Congenital Hypothyroidism in Fars Province, Iran

Mehrsadat Alavi; Hamdollah Karamifar; Golmhossein Amirhakimi; Zohreh Karamizadeh; Hedyeh Saneifard

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Evaluation of Congenital Hypothyroidism in Fars Province, Iran

Author(s):

Mehrsadat Alavi¹,

Hamdollah Karamifar²,

Golmhossein Amirhakimi²,

Zohreh Karamizadeh²,

Hedyeh Saneifard^2,*

1Department of Nuclear Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

2Division of endocrinology, Department of pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran

IJ Pediatrics:Vol. 22, issue 1; 107-112

Published online:Mar 31, 2012

Article type:Research Article

Received:Dec 25, 2010

Accepted:Dec 06, 2011

How to Cite:Mehrsadat AlaviHamdollah KaramifarGolmhossein AmirhakimiZohreh KaramizadehHedyeh SaneifardEvaluation of Congenital Hypothyroidism in Fars Province, Iran.Iran J Pediatr.22(1):107-112.

Abstract

Objective: In Iran thyroid-stimulating hormone (TSH) based neonatal screening program is included in health care services from 2005 for detection of patients with primary congenital hypothyroidism (CH). This study was performed for a critical evaluation of the screening program primary congenital hypothyroidism in Fars province, Iran.
Methods: From November 2006 to September 2007, TSH serum concentrations of 63031 newborns, 3 to 5 days old born in Fars province, were measured by heel prick. The newborns with TSH 5mIU/L were recalled for measurement of serumT4 and TSH in venous blood samples
Findings: Of 127 recalled subjects, 43 were confirmed to be hypothyroid, showing a prevalence of 1:1465 with F:M ratio of 1.05:1. The most common clinical and radiological findings were prolonged jaundice (73%), large anterior fontanel (56%), wide posterior fontanel (55%), absence of distal femoral epiphysis (20%), and umbilical hernia (11%). Scintigraphy of the thyroid with 99mTC revealed eutopia (67.4%), hypoplasia (23.3%), agenesis (4.7%) and ectopia (2.3%).
Conclusion: It is concluded that a cut off value of TSH≥5mIU/L overestimates recalling the number of patients with CH. The most common cause of congenital hypothyroidism is not dysgenesis of the gland and perhaps dyshormonogenesis in Iran is more common than what is reported in other countries.

Keywords

Congenital Hypothyroidism

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