Prevalence of Celiac Disease in Children with Autoimmune Hepatitis and vice versa

Kambiz  Eftekhari; Mehri  Najafi; Nooshin  Sadjadei; Ahmad  Khodadad; Farzaneh  Motamed; Gholam-Hossain  Fallahi; Fatemeh  Farahmand

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Prevalence of Celiac Disease in Children with Autoimmune Hepatitis and vice versa

Author(s):

Kambiz Eftekhari^1,*,

Mehri Najafi²,

Nooshin Sadjadei³,

Ahmad Khodadad⁴,

Farzaneh Motamed⁵,

Gholam-Hossain Fallahi⁶,

Fatemeh Farahmand⁷

IJ Pediatrics:Vol. 24, issue 6

Published online:Nov 28, 2014

Article type:Research Article

Received:Feb 05, 2014

Accepted:Jun 22, 2014

How to Cite:Kambiz EftekhariMehri NajafiNooshin SadjadeiAhmad KhodadadFarzaneh MotamedGholam-Hossain FallahiFatemeh Farahmandet al.Prevalence of Celiac Disease in Children with Autoimmune Hepatitis and vice versa.Iran J Pediatr.24(6):null-null.

Abstract

Objective: Celiac disease is an autoimmune disorder in which the risk of autoimmune liver disease is high. Autoimmune hepatitis is a chronic and progressive entity and the risk of its being associated with other autoimmune disorders such as celiac disease is high also. The aim of this study was to determine the prevalence of celiac disease in patients with autoimmune hepatitis and vice versa. Methods: In a cross-sectional study children with autoimmune hepatitis underwent serological screening and endoscopy for celiac disease. In patients with celiac disease, serum aminotransferases were measured and, if abnormal, autoantibodies related to autoimmune hepatitis were checked and needle liver biopsy was performed. Findings: Of the 96 patients, 64 had autoimmune hepatitis and 32 celiac disease. Among patients with autoimmune hepatitis only three (4.7%) were compatible with celiac disease. In the group of patients with celiac disease, autoimmune hepatitis was confirmed in four (12.5%) cases. We consider important to state that 3.1% of this group had celiac hepatitis. Conclusion: Autoimmune liver disease is sometimes associated with latent celiac disease. Serological screening for celiac disease should be routinely done in patients with abnormal serum aminotransferases, particularly those with chronic liver disease. On the other hand, celiac disease is often accompanied by other autoimmune diseases, including autoimmune hepatitis.

Keywords

Celiac Disease

Autoimmune Hepatitis

Anti Smooth Muscle Antibody

Anti Tissue Transglutaminase Antibody (tTG-IgA)

Anti-Nuclear Antibody

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