Evaluation of Oxidative Stress and Erythrocyte Properties in Children with Henoch-Shoenlein Purpura

authors:

avatar Dolunay Gurses 1 , * , avatar Nusret Parlaz 2 , avatar Melek Bor-Kucukatay 3 , avatar Vural Kucukatay 4 , avatar Gulten Erken 5

Iranian Journal of Pediatrics: Vol.24, issue 2; 166-172
published online: February 06, 2014
article type: Research Article
received: June 25, 2013
accepted: January 23, 2014

How To Cite Gurses D , Parlaz N , Bor-Kucukatay M, Kucukatay V, Erken G. Evaluation of Oxidative Stress and Erythrocyte Properties in Children with Henoch-Shoenlein Purpura. Iran J Pediatr. 2014;24(2): 166-172. 

Abstract

Objective: Pathogenesis of Henoch-Schönlein purpura (HSP) is not clearly defined. The present study was conducted to investigate the alterations in erythrocyte deformability and oxidative stress in HSP and to examine the possible relationship between erythrocyte deformability and organ involvement in this disease. Methods: Plasma malondialdehyde (MDA) levels, total antioxidant status (TAS), erythrocyte deformability and aggregation were measured in 21 children with HSP at the disease onset and during the remission period in comparison with healthy subjects. Findings: HSP patients at the active stage had significantly higher MDA and lower TAS levels (P<0.05). Erythrocyte deformability was decreased at the active-stage and increased again at the remission period of HSP (P<0.05). Erythrocyte deformability was significantly decreased at four different shear stresses in patients with gastrointestinal system or renal involvement; and decreased at six different shear stresses in patients with gastrointestinal system, and renal involvement compared to the patients without organ involvement (P<0.05). No significant difference was observed in aggregation parameters (P>0.05). Conclusion: The present findings emphasize the association between impaired erythrocyte deformability and organ involvement in HSP.
 

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