Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania

authors:

avatar Zahra Mirsepassi 1 , * , avatar Robabeh Mazinani 2 , avatar Farbod Fadai 2 , avatar Neda Alibeigi 3 , avatar Ali Nazeri-Astaneh 4

Resident, Razi Psychiatric Hospital, Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Psychiatrist, Associate Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Clinical Psychologist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Psychiatrist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Iranian Journal of Psychiatry and Behavioral Sciences: Vol.7, issue 2; 11-5
published online: December 30, 2013
article type: Original Article
received: February 28, 2013
revised: March 30, 2013
accepted: September 19, 2013

how to cite: Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania. Iran J Psychiatry Behav Sci. 2013;7(2): 11-5. 

Abstract

Objective: The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania.
Methods: In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly.
Results: In both intervention and control groups, YMRS score had significant decline after 8 weeks (p < 0.001), but there was no statistically significant difference between the two groups (p = 0.419). The highest score decline was after two weeks. YMRS score at baseline did not have statistically significant difference between the intervention and control groups (p = 0.709).
Conclusions: This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those with acute manic.
Declaration of interest: None. Clinical Trial Registration: URL: http://www.irct.ir. IRCT201110317960N1.
Citation: Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate add-on lithium carbonate for treatment of acute mania. Iran J Psychiatry Behav Sci 2013; 7(2): 11-5

Fulltext

Full text is available in the PDF.

References

  • 1.

    References are available in the PDF.