Imaging Review of Neurofibromatosis: Helpful Aspects for Early Detection

A Hekmatnia; Amirhossein Ghazavi; M J Marashi Shooshtari; F Hekmatnia; R Basiratnia

IJ Radiology

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Imaging Review of Neurofibromatosis: Helpful Aspects for Early Detection

Author(s):

A Hekmatnia¹,

Amirhossein Ghazavi^2,*,

M J Marashi Shooshtari³,

F Hekmatnia⁴,

R Basiratnia⁵

1Associated Professor, Department of Radiology-Image Processing and Signal Research Center, Department of Radiology, Isfahan, Iran

2Resident of Radiology, Isfahan, Iran

3Assistant Professor, Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran

4Medical Student, University of London, London, UK

5Isfahan, Iran

IJ Radiology:Vol. 8, issue 2; e93671

Published online:Jun 30, 2011

Article type:Case Report

Received:May 14, 2019

Accepted:Jun 30, 2011

How to Cite:A HekmatniaAmirhossein GhazaviM J Marashi ShooshtariF HekmatniaR BasiratniaImaging Review of Neurofibromatosis: Helpful Aspects for Early Detection.I J Radiol.8(2):e93671.

Abstract

Neurofibromatosis (NF) is divided into two types, NF type 1 and NF type 2. NF 2 is a complex of cutaneous and deep neural tumors. It is an autosomal dominant familial disorder in which CNS is affected in about 15% of the cases. Optic nerve gliomas have a high degree of association with NF type 1. NF type 2 is much less commonly seen. It is inherited as an autosomal dominant condition. Bilateral acoustic neuromas are pathognomonic of NF type 2 which may be associated with meningiomas or ependymomas.
Typical clinical manifestations of neurofibromatosis are cafe-au-lait spots and multiple cutaneous tumors. There is bone involvement as scoliosis, pseudoarthrosis of long bones, scalloping of vertebral bodies, abnormal rib tubulation and defective ossification of the skull. Extraskeletal manifestations of neurofibromatosis include optic nerve gliomas, pheochromocytoma, aneurysms of cerebral and renal arteries, acoustic neurilemmoma and superficial skin nodular neurofibromas.
Here, we intend to present images of several cases of neurofibromatosis with different aspects of body involvement.

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