Comparison of Continuous and Non-Continuous Aerobic Exercise on Serum Vascular Endothelial Growth Factor and Endostatin in Rats with Coronary Artery Disease

authors:

avatar Elham Dehghan ORCID 1 , avatar Reza Nouri ORCID 2 , * , avatar Ali Asghar Ravasi ORCID 3 , avatar Maryam Nekooei ORCID 4

Department of Exercise Physiology, Kish International Campus, University of Tehran, Kish, IR Iran
Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, IR Iran
Department of Sport Physiology, University of Tehran, Tehran, IR Iran
Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, IR Iran
International Cardiovascular Research Journal: Vol.14, issue 2; e101280
published online: June 15, 2020
article type: Research Article
received: January 22, 2020
accepted: May 31, 2020

how to cite: Dehghan E, Nouri R, Ravasi A A, Nekooei M . Comparison of Continuous and Non-Continuous Aerobic Exercise on Serum Vascular Endothelial Growth Factor and Endostatin in Rats with Coronary Artery Disease. Int Cardiovasc Res J. 2020;14(2):e101280. 

Abstract

Background:
Physical activities are associated with a decreased risk of Coronary Heart Disease (CHD), which is one of the widespread Cardiovascular Diseases (CVDs).
Objectives: The present study aimed to compare the effects of continuous and non-continuous aerobic exercises on serum Vascular Endothelial Growth Factor (VEGF) and Endostatin (ES) in rats with coronary artery disease.
Methods: In this study, 40 healthy male Wistar rats (age: two months, weight: 200 - 250 g) were divided into continuous and non-continuous aerobic exercises with Myocardial Infarction (MI), control, and sham groups. After treatment of the rats by Isoproterenol (ISO), the experimental groups underwent continuous and non-continuous aerobic exercises on a treadmill for eight weeks. The means of the variables were compared using ANOVA. Moreover, Scheffe’s post hoc test was used to clarify the exact zones of differences in the SPSS 21 software (P ≤ 0.05).
Results: The results demonstrated that both continuous and non-continuous aerobic exercises increased VEGF in comparison to the control group (P = 0.001). However, no significant difference was observed between the experimental groups and the control group with respect to ES (P = 0.09).
Conclusion: Continuous and non-continuous aerobic exercises could increase angiogenesis in coronary artery disease. Moreover, both methods might have the same positive effect on rehabilitation of patients with MI. Therefore, such exercises could be used as a complementary treatment alongside medications for MI patients.

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