Evaluation of the Incidence of Major Adverse Cardiac and Cerebrovascular Events after Percutaneous Coronary Intervention or Coronary Artery Bypass Graft on Proximal Left Anterior Descending Artery with and without Other Coronary Arteries Involvement

Behshad  Naghshtabrizi; Zahra  Sohrabi; Farzad  Emami; Babak  Manafi; Shafee  Membari

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Evaluation of the Incidence of Major Adverse Cardiac and Cerebrovascular Events after Percutaneous Coronary Intervention or Coronary Artery Bypass Graft on Proximal Left Anterior Descending Artery with and without Other Coronary Arteries Involvement

Author(s):

Behshad Naghshtabrizi^1,*,

Zahra Sohrabi¹,

Farzad Emami¹,

Babak Manafi²,

Shafee Membari¹

1Department of Cardiology, Ekbatan University Hospital, Hamadan University of Medical Sciences, Hamadan, Iran

2Department of Cardiac Surgery, Ekbatan University Hospital, Hamadan University of Medical Sciences, Hamadan, Iran

International Cardiovascular Research Journal:Vol. 10, issue 2; e10281

Published online:Jul 01, 2016

Article type:Research Article

Received:Dec 21, 2014

Accepted:Aug 19, 2015

How to Cite:Behshad NaghshtabriziZahra SohrabiFarzad EmamiBabak ManafiShafee MembariEvaluation of the Incidence of Major Adverse Cardiac and Cerebrovascular Events after Percutaneous Coronary Intervention or Coronary Artery Bypass Graft on Proximal Left Anterior Descending Artery with and without Other Coronary Arteries Involvement.Int Cardiovasc Res J.10(2):e10281.

Abstract

Background: Major Adverse Cardiac and Cerebrovascular Events (MACCE) include cardiac death, nonfatal Myocardial Infarction (MI), cerebrovascular events, and Target Vessel Revascularization (TVR) that may happen after Percutaneous Coronary Intervention (PCI) or Coronary Artery Bypass Graft (CABG).
Objectives: This study aimed to compare the incidence of MACCE between the patients who underwent PCI or CABG due to significant Left Anterior Descending (LAD) stenosis with and without other coronary arteries involvement.
Patients and Methods: This randomized mixed cohort study was conducted on 400 patients with Coronary Artery Disease (CAD), 200 with proximal LAD stenosis and 200 with non-proximal LAD stenosis, selected through census. Half of each group underwent PCI and the rest underwent CABG. The participants were followed at fixed intervals after the procedure and the incidence of MACCE was documented in their checklists. Then, relative risk index was used to compare the two groups regarding the incidence of MACCE. Statistical analysis was done using the Stata software, version 11 and P < 0.05 was considered to be statistically significant.
Results: The study participants included 281 males and 119 females with the mean age of 61.36 ± 10.66 years. The results showed a significant difference between the two groups regarding the incidence of MACCE (31.58% vs. 3%, P = 0.001). However, no significant difference was found between the effects of PCI with drug eluting stent and CABG on proximal LAD (3.70% vs. 3%, P = 1.00).
Conclusions: Considering the incidence of MACCE, CABG had no superiority over DES for proximal LAD stenosis.

Keywords

Percutaneous Coronary Intervention

Coronary Artery Bypass

Coronary Artery Disease

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