Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study

Oğuz  Karaca; Anıl  Avcı; Gamze  Babur G&uuml;ler; Onur  Omaygenc; Beytullah  Cakal; Haci Murat  Gunes; Elnur   Alizade; Ali  Metin Esen; Irfan  Barutcu; Bilal   Boztosun

International Cardiovascular Research Journal

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Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study

Author(s):

Oğuz Karaca ^1,*,

Anıl Avcı²,

Gamze Babur Güler ¹,

Onur Omaygenc ¹,

Beytullah Cakal¹,

Haci Murat Gunes¹,

Elnur Alizade²,

Ali Metin Esen²,

Irfan Barutcu ²,

Bilal Boztosun²

1Department of Cardiology, Faculty of Medicine, Medipol University, Istanbul, Turkey

2Department of Cardiology, Kartal Koşuyolu Heart and Research Hospital, Istanbul, Turkey

International Cardiovascular Research Journal:Vol. 10, issue 1; e10307

Published online:Mar 01, 2016

Article type:Research Article

Received:Jan 17, 2015

Accepted:Aug 19, 2015

How to Cite:Oğuz Karaca Anıl AvcıGamze Babur Güler Onur Omaygenc Beytullah CakalHaci Murat GunesElnur AlizadeAli Metin EsenIrfan Barutcu Bilal Boztosunet al.Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study.Int Cardiovasc Res J.10(1):e10307.

Abstract

Background: Right Ventricular (RV) functions are known to have an impact on determining the prognosis of patients with Non-Ischemic Dilated Cardiomyopathy (NICMP).

Objectives: This study aimed to investigate the echocardiographic determinants of RV systolic dysfunction in patients with NICMP.

Patients and Methods: This cross-sectional study was conducted on 79 patients with angiographically normal coronary arteries (mean age: 50.5 ± 12, mean Ejection Fraction (EF): 31 ± 4%) selected through purposive sampling The patients were divided into two groups based on their RV systolic function determined by tissue Doppler systolic velocities (RV-Sm): group A (RV-Sm ≥ 10 cm/s, N = 48) and group B (RV-Sm < 10 cm/s, N = 31). The two groups were compared regarding clinical, demographic, and echocardiographic variables using independent t-test and chi-square test.

Results: The patients with RV systolic dysfunction were found to have higher Brain Natriuretic Peptide (BNP) values (P = 0.006) and worse functional status (New York Heart Association (NYHA) III-IV, P = 0.04) compared to group A. Besides, univariate analysis of the echocardiographic parameters revealed that the patients in group B had significantly (all P values < 0.05) higher Left Atrial Volume Index (LAVI), higher degree of left ventricular diastolic dysfunction (represented by LV-E/Em), higher degree of Functional Mitral Regurgitation (FMR), higher estimated Pulmonary Artery Systolic Pressure (PASP), and higher degree of RV diastolic dysfunction (represented by RV-E/Em) Moreover, multivariate logistic regression analysis showed that severe FMR (P = 0.006) and RV-E/Em (P = 0.016) predicted RV systolic dysfunction independently.

Conclusions: Advanced FMR and worse RV diastolic functions emerged as the independent predictors of RV systolic dysfunction in NICMP correlating to functional status and BNP levels.

Keywords

Dilated Cardiomyopathy

Right Ventricle

Echocardiography

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