The Effect of Vitamin D Deficiency Treatment on Post-PCI Coronary Restenosis and Major Adverse Cardiac Events

Davood   Kazemi Saleh; Zahra   Jozanikohan

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards & Committees Indexing and Listing Sources Journal Metrics Publication Ethics and Publication Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

The Effect of Vitamin D Deficiency Treatment on Post-PCI Coronary Restenosis and Major Adverse Cardiac Events

Author(s):

Davood Kazemi Saleh¹,

Zahra Jozanikohan^2,*

1Department of Cardiology, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

2Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

International Cardiovascular Research Journal:Vol. 10, issue 1; e10308

Published online:Mar 01, 2016

Article type:Research Article

Received:Feb 11, 2015

Accepted:Jun 10, 2015

How to Cite:Davood Kazemi SalehZahra JozanikohanThe Effect of Vitamin D Deficiency Treatment on Post-PCI Coronary Restenosis and Major Adverse Cardiac Events.Int Cardiovasc Res J.10(1):e10308.

Abstract

Background: Evidence have shown the relationship between vitamin D deficiency and cardiovascular disease.

Objectives: The present study aimed to evaluate the effect of Vitamin D deficiency treatment on the occurrence of coronary post-Percutaneous Intervention (PCI) restenosis and Major Adverse Cardiac Events (MACE).

Patients and Methods: This randomized semi-experimental non-controlled study was conducted on patients with coronary artery disease who were candidate for PCI and had referred to Baqiyatallah Hospital in a 2-month period. The patients with normal Vitamin D levels were allocated to the normal group and others were randomly assigned to treatment and non-treatment groups. All the patients were followed for 9 months. Vitamin D was measured again at the end of the 9th month and the patients were reassigned to normal and mild, moderate, and severe deficiency groups with respect to Holick classification.

Results: This study was performed on 150 subjects with the mean age of 62.46 ± 10.80 years and male/female ratio of 94/56. The results showed no significant difference among the three groups regarding age, gender, diabetes, number of cardiovascular risk factors, and other underlying risk factors for restenosis. However, a significant difference was found between the patients with normal and abnormal vitamin D levels regarding the number of stenotic vessels and number of PCIs (both P < 0.001). Nonetheless, no significant difference was found between the treated and non-treated groups regarding the number of stenotic vessels and number of PCIs (P > 0.05). At the end of the study, 32 (55.1%) out of the 58 patients (55.1%) who were deficient reached normal vitamin D levels by consuming supplements, but 7 (12%) reached normal values without using supplements (P < 0.001).

Conclusions: Treatment of vitamin D deficiency could reduce restenosis of PCI. However, this protocol is efficient for patients with moderate to severe deficiency and should be changed.

Keywords

Vitamin D

Coronary Artery Disease

Percutaneous Coronary Intervention

Fulltext

The full text is available in PDF.

References

1.
The references are available in PDF.

comments