Gender-Related Differences in Presentation and Outcome of Acute Type a Aortic Dissection

Leili Pourafkari; Samad Ghaffari; Arezou Tajlil; Naser Safaei; Razieh Parizad; Mohammadreza Chavoshi; Kasra Kolahdouzan; Nader Nader

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Gender-Related Differences in Presentation and Outcome of Acute Type a Aortic Dissection

Author(s):

Leili Pourafkari¹,

Samad Ghaffari¹,

Arezou Tajlil¹,

Naser Safaei¹,

Razieh Parizad¹,

Mohammadreza Chavoshi¹,

Kasra Kolahdouzan¹,

Nader Nader^2,*

1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2Anesthesiology Department, University at Buffalo, Buffalo, New York, United States

International Cardiovascular Research Journal:Vol. 11, issue 3; e10427

Published online:Sep 01, 2017

Article type:Research Article

Received:Aug 21, 2017

Accepted:May 10, 2017

How to Cite:Pourafkari L, Ghaffari S, Tajlil A, Safaei N, Parizad R, et al. Gender-Related Differences in Presentation and Outcome of Acute Type a Aortic Dissection. Int Cardiovasc Res J. 2017;11(3):e10427. doi:

Abstract

Background: Although acute type-A aortic dissection (AAOD) is more common in
males, the course of the disease may differ in females.
Objectives: We aimed to investigate the gender-related differences in patients with
AAOD with regard to clinical presentation, short-term and long-term mortality.
Patients and Methods: Medical records of 192 patients with a confirmed diagnosis
of AAOD in a University Heart Center from March 2004 through October 2015 were
evaluated. Clinical information, hospital mortality, and long-term survival were
explored with regard to gender. Propensity matching was performed to adjust for
baseline differences. Kaplan-Meier survival analysis was used to determine the impact
of gender on long-term mortality.
Results: Among 192 patients, 71 (37.0%) were females. The women were older (65.7 ±
13.8 vs. 53.9 ± 15.1 years, P < 0.001). Hypertension (77.5% vs. 56.7%; P = 0.006) and
diabetes mellitus (12.7% vs. 0.1%; P = 0.001) were more common among women than
men, while active smoking was significantly more prevalent in men (46.7% vs. 9.9%; P <
0.001). The frequency of various clinical presentations was not different between the two
groups. Among men, 71.7% were surgically managed compared to 67.6% among women.
In-hospital mortality was 50.7% in women and 42.1% in men and remained statistically
similar after matching. For long-term survival female to male hazard ratio (HR) was
1.24 with 95% CI: 0.85 - 1.81 (P = 0.257), which basically remained unchanged after
propensity matching, HR was 1.13, 95%CI: 0.73 - 1.73 (P = 0.300).
Conclusions: In patients admitted with AAOD, there was no gender-related differences
in clinical presentation and type of management. Similarly, hospital and long-term
mortality did not differ with regard to gender.

Keywords

Gender

Aortic Disease

Female

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References

1.
The references are available in PDF.

Gender Disparities in Ankylosing Spondylitis: An Algerian Retrospective Analytical Cohort Study

Nassima Farah Beldja,

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Cervical Artery Dissection: A Review of the Epidemiology, Pathophysiology, Treatment, and Outcome

Christina A. Blum,

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Delivery of Optimum Management of Type B Aortic Dissection in the UK: Sum of All Fears!

Matti Jubouri,

Mohamad Bashir,

Damian Bailey,

Richard Anderson,

Christoph A Nienaber,

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Jubouri M, Bashir M, Bailey D, Anderson R, A Nienaber C, et al. Delivery of Optimum Management of Type B Aortic Dissection in the UK: Sum of All Fears!. Multidiscip Cardio Annal. 2022;13(1):e122216. doi: https://doi.org/10.5812/mca-122216

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Gender and Smoking-Related Survival Differences in Patients with ST-Elevation Myocardial Infarction

Parisa Janjani,

Sayeh Motevaseli,

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Janjani P, Motevaseli S, Salimi Y, Siabani S, Asadmobini A, et al. Gender and Smoking-Related Survival Differences in Patients with ST-Elevation Myocardial Infarction. Int Cardiovasc Res J. 2022;16(3):e128157. doi:

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Author(s):

Leili Pourafkari:[PubMed][Scholar]
Samad Ghaffari:[PubMed][Scholar]
Arezou Tajlil:[PubMed][Scholar]
Naser Safaei:[PubMed][Scholar]
Razieh Parizad:[PubMed][Scholar]
Mohammadreza Chavoshi:[PubMed][Scholar]
Kasra Kolahdouzan:[PubMed][Scholar]
Nader Nader:[PubMed][Scholar]

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Gender-Related Differences in Presentation and Outcome of Acute Type a Aortic Dissection

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