Gender-Related Differences in Presentation and Outcome of Acute Type a Aortic Dissection

Leili Pourafkari; Samad Ghaffari; Arezou Tajlil; Naser Safaei; Razieh Parizad; Mohammadreza Chavoshi; Kasra Kolahdouzan; Nader Nader

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards & Committees Indexing and Listing Sources Journal Metrics Publication Ethics and Publication Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Gender-Related Differences in Presentation and Outcome of Acute Type a Aortic Dissection

Author(s):

Leili Pourafkari¹,

Samad Ghaffari¹,

Arezou Tajlil¹,

Naser Safaei¹,

Razieh Parizad¹,

Mohammadreza Chavoshi¹,

Kasra Kolahdouzan¹,

Nader Nader^2,*

1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2Anesthesiology Department, University at Buffalo, Buffalo, New York, United States

International Cardiovascular Research Journal:Vol. 11, issue 3; e10427

Published online:Sep 01, 2017

Article type:Research Article

Received:Aug 21, 2017

Accepted:May 10, 2017

How to Cite:Leili PourafkariSamad GhaffariArezou TajlilNaser SafaeiRazieh ParizadMohammadreza ChavoshiKasra KolahdouzanNader Naderet al.Gender-Related Differences in Presentation and Outcome of Acute Type a Aortic Dissection.Int Cardiovasc Res J.11(3):e10427.

Abstract

Background: Although acute type-A aortic dissection (AAOD) is more common in
males, the course of the disease may differ in females.
Objectives: We aimed to investigate the gender-related differences in patients with
AAOD with regard to clinical presentation, short-term and long-term mortality.
Patients and Methods: Medical records of 192 patients with a confirmed diagnosis
of AAOD in a University Heart Center from March 2004 through October 2015 were
evaluated. Clinical information, hospital mortality, and long-term survival were
explored with regard to gender. Propensity matching was performed to adjust for
baseline differences. Kaplan-Meier survival analysis was used to determine the impact
of gender on long-term mortality.
Results: Among 192 patients, 71 (37.0%) were females. The women were older (65.7 ±
13.8 vs. 53.9 ± 15.1 years, P < 0.001). Hypertension (77.5% vs. 56.7%; P = 0.006) and
diabetes mellitus (12.7% vs. 0.1%; P = 0.001) were more common among women than
men, while active smoking was significantly more prevalent in men (46.7% vs. 9.9%; P <
0.001). The frequency of various clinical presentations was not different between the two
groups. Among men, 71.7% were surgically managed compared to 67.6% among women.
In-hospital mortality was 50.7% in women and 42.1% in men and remained statistically
similar after matching. For long-term survival female to male hazard ratio (HR) was
1.24 with 95% CI: 0.85 - 1.81 (P = 0.257), which basically remained unchanged after
propensity matching, HR was 1.13, 95%CI: 0.73 - 1.73 (P = 0.300).
Conclusions: In patients admitted with AAOD, there was no gender-related differences
in clinical presentation and type of management. Similarly, hospital and long-term
mortality did not differ with regard to gender.

Keywords

Gender

Aortic Disease

Female

Fulltext

The full text is available in PDF.

References

1.
The references are available in PDF.

comments

Leave a comment here

Import into EndNote Import into BibTex

Indexed in

Scopus

Share on

Comments

Number of Comments:0

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Leili Pourafkari:[PubMed][Scholar]
Samad Ghaffari:[PubMed][Scholar]
Arezou Tajlil:[PubMed][Scholar]
Naser Safaei:[PubMed][Scholar]
Razieh Parizad:[PubMed][Scholar]
Mohammadreza Chavoshi:[PubMed][Scholar]
Kasra Kolahdouzan:[PubMed][Scholar]
Nader Nader:[PubMed][Scholar]