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The Genetic Factors in the Development of Atrial Fibrillation


avatar Zulfiya Kachiyeva ORCID 1 , avatar Aiganym Tolegenkyzy 1 , avatar Timur Saliev ORCID 1 , avatar Shynar Tanabayeva ORCID 1 , avatar Baimakhan Tanabayev ORCID 2 , avatar Bakhyt Ramazanova ORCID 1 , avatar Ildar Fakhradiyev ORCID 1 , *

1 S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

2 South-Kazakhstan Medical Academy, Shymkent, Kazakhstan

How to Cite: Kachiyeva Z , Tolegenkyzy A, Saliev T , Tanabayeva S, Tanabayev B, et al. The Genetic Factors in the Development of Atrial Fibrillation. Int Cardio Res J. 2021;15(1):e108440.


International Cardiovascular Research Journal: 15 (1); e108440
Published Online: March 15, 2021
Article Type: Review Article
Received: August 10, 2020
Accepted: November 14, 2020


Context: Atrial Fibrillation (AF) is the most prevalent arrhythmia in human populations
with a growing world-wide burden. The present review aimed to determine the genetic
factors in the development of AF.
Evidence Acquisition: The present study included the studies, which probed into the
genetic factors of AF. The searches were done in PubMed, Scopus, Web of Science,
Embase, and Google Scholar databases. The review highlighted two main directions
of AF genetic studies; i.e., rare mutations in structural genes, including potassium
and sodium channels, connexins, and transcription factors genes, and genome-wide
association studies of significant common variants. The main focus was on the most
important loci confirmed by numerous studies with both rare and common variants.
Results: Research on the genetic basis of AF has remained a hot topic due to its growing
worldwide burden. Recent advances in genome-wide studies have provided the ground
for gaining insight on minor genetic factors with cumulative effects, which are distributed
more widely than previously known rare mutations.
Conclusions: Far more potential candidate genes and/or regulatory sequences have been
already discovered, and there are much more to be explored in the near future. This will
potentially result in a better understanding of AF and other arrhythmic conditions as
well as their impacts on human health, and will provide new ways to improve diagnostics
and treatment strategies.




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