Oral Selenium: Can It Prevent Contrast-Induced Nephropathy Following Coronary Angiography and Angioplasty

Hashem Danesh Sani; Moosa Karami Kharat; Mohammad Vejdanparast; Ali Eshraghi; Alireza Abdollahi Moghaddam; Hamid Eshraghi

doi:10.17795/icrj-9(4)226

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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https://doi.org/10.17795/icrj-9(4)226

Oral Selenium: Can It Prevent Contrast-Induced Nephropathy Following Coronary Angiography and Angioplasty

Author(s):

Hashem Danesh Sani¹,

Moosa Karami Kharat¹,

Mohammad Vejdanparast¹,

Ali Eshraghi^1,*,

Alireza Abdollahi Moghaddam¹,

Hamid Eshraghi²

1Atherosclerosis Prevention Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2Department of Internal Medicine, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

International Cardiovascular Research Journal:Vol. 9, issue 4; e10915

Published online:Dec 31, 2015

Article type:Research Article

Received:Jul 18, 2014

Accepted:Apr 08, 2015

How to Cite:Hashem Danesh SaniMoosa Karami KharatMohammad VejdanparastAli EshraghiAlireza Abdollahi MoghaddamHamid Eshraghiet al.Oral Selenium: Can It Prevent Contrast-Induced Nephropathy Following Coronary Angiography and Angioplasty.Int Cardiovasc Res J.9(4):e10915.https://doi.org/10.17795/icrj-9(4)226.

Abstract

Background: Alteration of kidney function called Contrast-Induced Nephropathy (CIN) is commonly encountered in diagnostic and interventional cardiology procedures. It results in considerable morbidity and mortality besides imposing significant costs on the healthcare system. Today, it is accounted as the third cause of hospital-acquired acute renal failure.
Objectives: Considering anti-oxidant and free radical scavenging properties of selenium and the role of free radicals in CIN, the present study aimed to investigate the effects of oral selenium (in the form of Se-yeast capsule) on preventing or decreasing the rate of CIN in patients undergoing angiography and angioplasty.
Patients and Methods: This prospective, non-randomized, single-blind, single-center clinical trial was conducted on 175 consecutive patients admitted for elective coronary angiography (N = 105) or angioplasty (N = 70). Selenium was prescribed as a single dose of 200 micrograms the day before and after the procedure. Routine hydration based on the ward protocol was administered for all the patients. For the control group, the researchers made use of the data of another survey performed in the same hospitals for determining the prevalence of CIN a year before. The data were analyzed using student’s t-test and logistic regression analysis and P < 0.05 was considered as statistically significant.
Results: Based on the results of student’s t-test, the mean difference between the two groups was significant only in hematocrit levels. The incidence of CIN was 9% in the selenium group compared to 22% in the control group (P = 0.027). There was no case of in-hospital mortality and none of the CIN patients required renal replacement therapy during hospitalization.
Conclusions: Prophylactic selenium administration may significantly reduce the incidence of CIN.

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Author(s):

Hashem Danesh Sani:[PubMed][Scholar]
Moosa Karami Kharat:[PubMed][Scholar]
Mohammad Vejdanparast:[PubMed][Scholar]
Ali Eshraghi:[PubMed][Scholar]
Alireza Abdollahi Moghaddam:[PubMed][Scholar]
Hamid Eshraghi:[PubMed][Scholar]