Kinetics of Orthostatic Blood Pressure in Primary Hypertension

Fatima Zahra  Milouk; Mustapha  El Bakkali; Leslie  Coghlan; Amal  Lachhab; Souad  Aboudrar; Halima  Benjelloun

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Kinetics of Orthostatic Blood Pressure in Primary Hypertension

Author(s):

Fatima Zahra Milouk¹,

Mustapha El Bakkali^2,*,

Leslie Coghlan³,

Amal Lachhab²,

Souad Aboudrar²,

Halima Benjelloun⁴

1Unit of Cardiology A, Ibn Sina University Hospital, Rabat 10000, Morocco

2Autonomic Nervous System Team (ERSNA), Faculty of Medicine and Pharmacy, University Mohammed V Souissi, Rabat 6203, Morocco

3School of Science and Engineering, AL Akhawayn University, Ifrane, Morocco

4Research Center for Clinical Epidemiology and Therapeutic Trials (CRECET), Faculty of Medicine and Pharmacy, University Mohammed V Souissi, Rabat 6203, Morocco

International Cardiovascular Research Journal:Vol. 8, issue 3; e11054

Published online:Jun 30, 2014

Article type:Research Article

Received:Feb 18, 2017

Accepted:Apr 29, 2014

How to Cite:Fatima Zahra MiloukMustapha El BakkaliLeslie CoghlanAmal LachhabSouad AboudrarHalima Benjellounet al.Kinetics of Orthostatic Blood Pressure in Primary Hypertension.Int Cardiovasc Res J.8(3):e11054.

Abstract

Background: Primary Hypertension (HT) is the most prevalent cardiovascular disorder worldwide and is accompanied by significant morbidity and mortality.

Objectives: The present study aimed to investigate the kinetics of orthostatic Blood Pressure (BP) in primary hypertensive patients during the change from supine position to standing position as well as during the standing position using the Orthostatic Test (OT).

Patients and Methods: This prospective study included a group of 107 primary hypertensive patients (mean age: 55.82 ± 11.35 years, ranging from 39 to 80 years). Orthostatic systolic BP (Ortho SBP) was recorded for 10 minutes at the rhythm of 3 measurements per minute and was compared to the values of supine systolic preorthostatic (Preortho SBP). According to the changes in Ortho SBP, three subgroups of primary hypertensive patients were selected as follows: Subgroup A: Ortho SBP was higher than mean Preortho SBP by 10 mmHg or more. Subgroup B: Ortho SBP was lower than mean Preortho SBP by 20 mmHg or more. Subgroup C: -20 mmHg < (Ortho SBP - Preortho SBP) < + 10 mmHg.

Results: In this study, the prevalence of subgroups A, B, and C was 27.1%, 15.9%, and 57.0%, respectively. In subgroup A, the adrenergic peripheral sympathetic alpha response was 20% during the OT.

Conclusions: Hypertensives with very similar supine SBP behavior could exhibit widely different Ortho SBP. Thus, careful and effective treatment of hypertensives requires careful consideration and assessment of orthostatic BP.

Keywords

Primary Hypertension

Autonomic Nervous System

Orthostatic Hypotension

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