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Long Term Follow up of Cardiac Calcified Amorphous Tumor in Major Thalassemia; A case series report


avatar Mojgan Parsaie ORCID 1 , avatar Mohaddeseh Behjati ORCID 1 , *

1 Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

How to Cite: Parsaie M, Behjati M. Long Term Follow up of Cardiac Calcified Amorphous Tumor in Major Thalassemia; A case series report. Int Cardio Res J. 2021;15(3):e110787.


International Cardiovascular Research Journal: 15 (3); e110787
Published Online: September 15, 2021
Article Type: Case Report
Received: September 29, 2020
Revised: July 23, 2021
Accepted: August 15, 2021


heart intracavitary mass lesions. Cardiac CATs may arise in any heart chamber and are
characterized histopathologically by diffuse calcium infiltration. The recommended
treatment of choice is complete resection of the mass through surgery. Herein, three cases
with thalassemia were presented with significant CATs that remained asymptomatic
during close observation without any surgical interventions.
Case Presentation: The three patients suffered from thalassemia. One of them had
a calcified mass (3.8 × 0.74 cm) in the right ventricle in the vicinity of ventricular
trabeculations, which prolapsed into the tricuspid valve orifice that resulted in moderate
to severe tricuspid regurgitation without the development of any stenosis. Another case
had an irregular calcified mass (2.3 × 0.75 cm) in the roof of the left atrium. The third case
had a large calcified mass with a mobile component in right ventricular trabeculation.
Surgical resection of the mass was recommended in all the cases, but they were closely
monitored without surgical intervention. During the five-year follow-up, they remained
totally asymptomatic and had no cardiovascular or cerebral events.
Conclusions: Immobile CATs in patients with thalassemia can be asymptomatic. Hence,
they can be closely monitored and surgical intervention can be delayed for many years.


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