Left Ventricular Mechanics in Isolated Rheumatic Mitral Stenosis ;Impact of loading condition on different parameters of left ventricular function

Atoosa Mostafavi; Azin Alizadehasl; Shahin  Shirani

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards & Committees Indexing and Listing Sources Journal Metrics Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

Left Ventricular Mechanics in Isolated Rheumatic Mitral Stenosis ;Impact of loading condition on different parameters of left ventricular function

Author(s):

Atoosa Mostafavi

¹,

Azin Alizadehasl

^2,*,

Shahin Shirani

³

1Department of Echocardiography, Tehran University of Medical Sciences, Dr. Ali Shariati Hospital, Tehran, IR Iran

2Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran

3Cardiology Department, Tehran University of Medical Science, Shariati Hospital, Tehran, IR Iran

International Cardiovascular Research Journal:Vol. 15, issue 2; e111814

Published online:Jun 30, 2021

Article type:Research Article

Received:Dec 01, 2020

Accepted:Aug 06, 2021

How to Cite:Mostafavi A, Alizadehasl A, Shirani S. Left Ventricular Mechanics in Isolated Rheumatic Mitral Stenosis ;Impact of loading condition on different parameters of left ventricular function. Int Cardiovasc Res J. 2021;15(2):e111814. doi:

Abstract

Background: Rheumatic mitral stenosis leads to depressed ventricular function, which is not detectable through the measurement of ejection fraction. Whether pancarditis or changes in loading condition results in subclinical Left Ventricular (LV) dysfunction has yet to be fully elucidated.
Objectives: The aim of this study is to evaluate the effect of loading condition on left ventricular function.
Methods: The present observational, case-control study was conducted on 104 cases who were referred to the echocardiography department including 71 patients with different severity degrees of rheumatic mitral stenosis and 33 healthy individuals with no past history of cardiac or other medical illnesses and with normal echocardiography who were matched with the cases in terms of age, gender, and body surface area. The strain, strain rate, rotation, torsion, and twist parameters of the left ventricle were measured via 2D speckle-tracking echocardiography. The data were analyzed using Kolmogorov–Smirnov test, independent student t-test, and one-way Analysis of Variance (ANOVA), as appropriated. Correlation analysis was also performed using linear regression, and the results were expressed as Pearson’s correlation coefficients.
Results: The LV Global Longitudinal Strain (GLS), Global Longitudinal Strain Rate (GLsr), and Global Circumferential Strain Rate (GCsr), but not Global Circumferential Strain (GCS), basal and apical rotations, twist, and torsion, were significantly lower in the subgroup with progressive mitral stenosis (17.7%, 1.07s-1, 22.85%, and 1.05s-1, respectively) compared to the healthy group (19.76%, 1.17 s-1, 24.15%, and 1.27 s-1, respectively) (P = 0.001, 0.032, 0.104, and < 0.001, respectively). Increase in the severity degree of mitral stenosis was accompanied by a significant decrease in the mentioned parameters.
Conclusions: The rheumatic process led to a reduction in ventricular function, which was detectable through the measurement of the GLS, GLsr, and GCsr, but not GCS, twist, rotation, and torsional parameters of the left ventricle. As the severity of the stenosis progressed, other indices of the LV function such as rotation, twist, and torsion decreased significantly, indicating their more susceptibility to loading conditions compared to the rheumatic process per se.

Keywords

Fulltext

The full-text is available in pdf.

References

1.
The references are available in pdf.

Import into EndNote Import into BibTex

Indexed in

Web of Sciences Core Collections

Scopus

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 2 weeks ago
Scopus by Title: 0
Last Update: 2 weeks ago
Scopus by Title (Ref): 0
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 5 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Atoosa Mostafavi:[PubMed][Scholar]
Azin Alizadehasl:[PubMed][Scholar]
Shahin Shirani:[PubMed][Scholar]

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Outlines

Left Ventricular Mechanics in Isolated Rheumatic Mitral Stenosis ;Impact of loading condition on different parameters of left ventricular function

Abstract

Fulltext

References

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 5 days ago