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The Prevalence of Cardiovascular Risk Factors in Fatal Cases of COVID-19 in Fars Province, Iran


avatar Mohammad Javad Zibaeenezhad ORCID 1 , avatar Mehrab Sayadi ORCID 2 , avatar Hamed Bazrafshan 2 , avatar Zahra Daneshvar ORCID 2 , avatar Nader Parsa 2 , avatar Navid Farshadi 2 , avatar MohammadReza Hatamnejad ORCID 2 , avatar Mehdi Bazrafshan 2 , avatar Alireza Estedlal 2 , avatar Mehran khademalizade 2 , avatar Mohammad Zarenezhad 3 , avatar Zahra Elyaspour ORCID 2 , avatar Iman Razeghian-Jahromi ORCID 2 , *

1 Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran

3 Iranian Legal Medicine Research Center, Legal Medicine Organization, Tehran, IR Iran

How to Cite: Zibaeenezhad M J , Sayadi M, Bazrafshan H, Daneshvar Z , Parsa N, et al. The Prevalence of Cardiovascular Risk Factors in Fatal Cases of COVID-19 in Fars Province, Iran. Int Cardio Res J. 2021;15(1):e112945.


International Cardiovascular Research Journal: 15 (1); e112945
Published Online: March 30, 2021
Article Type: Research Article
Received: January 12, 2021
Accepted: February 20, 2021


Background: Human health has been challenged drastically by the emergence of
COVID-19. This pandemic has imposed a serious burden on different aspects of life.
Apart from the high rates of morbidity and mortality, reporting of newly formed variants
with enhanced contagious capacity has made the future vague. Existence of different
comorbidities is a prominent factor towards poor prognosis and fatal outcomes.
Objectives: The present study aimed to identify the most important comorbidities in the
COVID-19 patients who passed away during the first wave in Fars province, Iran.
Methods: Trained general physicians obtained data from medical files in the referral
hospitals of COVID-19 throughout the province. These included demographic data, past
medical history, and existence of comorbidities. The data were analyzed using chi-square
test, independent sample t-test, and Mann-Whitney test. P-values less than 0.05 were
considered statistically significant.
Results: Out of the 3700 confirmed cases, 87 patients died from February to May 2020.
Among these patients, 81.1% had comorbidities, with hypertension, diabetes, and
cardiovascular disease being the most prevalent ones. The results revealed no significant
differences between the individuals with and without comorbidities regarding age,
gender, and duration of ICU hospitalization. Oxygen saturation was also poor in both
groups. However, the patients with comorbidities had significantly higher blood urea
nitrogen and creatinine levels compared to their comorbidity-free peers.
Conclusions: Cardiovascular disease and the related risk factors contributed greatly
to the deadly fate in COVID-19 patients. Hence, early prophylactic and therapeutic
interventions should be considered in COVID-19 patients harboring such comorbidities.
This can play a pivotal role in reducing the rate of mortality and the consequent financial
and social harms.


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© 2021, Shiraz University of Medical Sciences.