Comparison of Calcitonin Gene Related Peptide Level between Children with Dilated Cardiomyopathy and Control Group

Noormohammad  Noori; Iraj Shahramian; Maziar  Mahjoobifar; Alireza  Teymoori; Zahra  Shahraki

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards & Committees Indexing and Listing Sources Journal Metrics Publication Ethics and Publication Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Comparison of Calcitonin Gene Related Peptide Level between Children with Dilated Cardiomyopathy and Control Group

Author(s):

Noormohammad Noori¹,

Iraj Shahramian^2,*,

Maziar Mahjoobifar¹,

Alireza Teymoori¹,

Zahra Shahraki¹

1Children and Adolescents Health Research Center, Zahedan Medical University, Zahedan, Iran

2Department of Pediatric, Zabol University of Medical Sciences, Zabol, Iran

International Cardiovascular Research Journal:Vol. 9, issue 2; e11403

Published online:Jun 30, 2015

Article type:Research Article

Received:Mar 12, 2017

Accepted:Dec 03, 2014

How to Cite: Noormohammad NooriIraj ShahramianMaziar MahjoobifarAlireza TeymooriZahra ShahrakiComparison of Calcitonin Gene Related Peptide Level between Children with Dilated Cardiomyopathy and Control Group.Int Cardiovasc Res J.9(2):e11403.

Abstract

Background: Dilated cardiomyopathy is revealed with left ventricular dilatation and systolic dysfunction.

Objectives: This study aimed to compare the children with dilated cardiomyopathy and control group regarding the level of Calcitonin Gene Related Peptide (CGRP) and its relationship with echocardiography findings

Patients and Methods: This case-control study was conducted on 37 children with dilated cardiomyopathy and free of any clinical symptoms and 37 healthy age- and sex-matched children referring to Ali-e-Asghar and Ali Ebne Abitaleb hospitals in Zahedan, Iran. After taking history, echocardiography was performed for both groups. The data were analyzed using the SPSS statistical software and appropriate statistical tests.

Results: The two groups were significantly different regarding most of the echocardiographic parameters (P < 0.05). Also, a significant difference was found between the two groups concerning the mean CGRP levels (P = 0.001). Among echocardiographic parameters, CGRP was directly related to Interventricular Septal dimension in Systole (IVSS) (P = 0.022, R = 0.375). However, no significant relationship was observed between CGRP level and Ross classification.

Conclusions: The findings of this study showed an increase in CGRP serum levels in the case group. Besides, a direct correlation was observed between CGRP level and IVSS.

Keywords

Calcitonin Gene-Related Peptide

Dilated Cardiomyopathy

Children

Fulltext

The full text is available in PDF.

References

1.
The references are available in PDF.

comments