Sildenafil Improves Erectile Function in Men with Chronic Heart Failure

authors:

avatar Niloufar Samiei 1 , avatar Ahmad Amin 2 , * , avatar Mitra Chitsazan 3 , avatar Mohammad Safarian 3 , avatar Sepideh Taghavi 2

Heart Valve Disease Research Center, Rajaei Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran
Department of Heart Failure and Transplantation, Rajaei Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran
Rajaei Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran
International Cardiovascular Research Journal: Vol.9, issue 2; e11405
published online: June 30, 2015
article type: Research Article
received: March 12, 2017
accepted: October 01, 2014

how to cite: Samiei N , Amin A, Chitsazan M, Safarian M , Taghavi S . Sildenafil Improves Erectile Function in Men with Chronic Heart Failure. Int Cardiovasc Res J. 2015;9(2):e11405. 

Abstract

Background: Patients with Chronic Heart Failure (CHF) have been shown to have enhanced risk of Erectile Dysfunction (ED) due to low cardiac output, endothelial dysfunction, medications, co-morbid conditions, and psychogenic factors.
Objectives: The present study aimed to evaluate the effects of sildenafil on erectile function of patients with stable CHF using the abridged 5-item version of the International Index of Erectile Function (IIEF-5).
Patients and Methods: Using convenience sampling, 222 sexually-active adult males with NYHA class I-III stable CHF were included in this cross-sectional study. All the patients filled out the IIEF-5 questionnaire, in which they were required to score the five domains of male sexual function, including erectile function, orgasm function, sexual desire, intercourse satisfaction, and overall satisfaction. All the analyses were performed using the SPSS statistical software (v. 19) and P < 0.05 was considered as statistically significant.
Results: In our sample, the patients’ mean age was 47.14 ± 11.86 years, their mean left ventricular ejection fraction was 20% (15% - 25%), and the prevalence of ED was 70.3%. In addition, severe, moderate, mild to moderate, and mild ED were seen in 57%, 17%, 7%, and 19% of the patients with ED, respectively. ED was significantly more prevalent in the patients with ischemic heart failure compared to those with idiopathic dilated cardiomyopathy (84.68% vs. 55.85%, P < 0.001). Moreover, the prevalence of ED was significantly lower in the patients taking sildenafil compared to the other group (42.85% vs. 82.89%, P < 0.001).
Conclusions: Sildenafil appears to provide satisfactory results toward improving sexual function in patients with CHF.

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References

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