QT Dispersion after Thrombolytic Therapy

Saeed  Oni Heris; Behzad  Rahimi; Gholamreza  Farid aalaee; Mojgan  Hajahmadi; Hojjat  Sayyadi; Bahman  Naghipour

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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QT Dispersion after Thrombolytic Therapy

Author(s):

Saeed Oni Heris¹,

Behzad Rahimi²,

Gholamreza Farid aalaee^3,*,

Mojgan Hajahmadi²,

Hojjat Sayyadi⁴,

Bahman Naghipour⁵

1Shahid Rajaee Heart Center, Tehran, Iran

2Cardiology Department, Urmia University of Medical Sciences, Urmia, Iran

3Emergency Medicine Department, Urmia University of Medical Sciences, Urmia, Iran

4Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5Department of Anesthesiology, Madani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

International Cardiovascular Research Journal:Vol. 8, issue 4; e11681

Published online:Dec 01, 2014

Article type:Research Article

Received:Apr 19, 2017

Accepted:Jul 16, 2014

How to Cite:Saeed Oni HerisBehzad RahimiGholamreza Farid aalaeeMojgan HajahmadiHojjat SayyadiBahman Naghipouret al.QT Dispersion after Thrombolytic Therapy.Int Cardiovasc Res J.8(4):e11681.

Abstract

Background: QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI).

Objectives: This study aimed to assess the effect of thrombolytic therapy on QTd before and 1 hour and 4 days after beginning of thrombolytic therapy.

Patients and Methods: The patients with chest pain and ST Elevated Myocardial Infarction (STEMI) that underwent thrombolytic therapy were enrolled into this study. Streptokinase was the thrombolytic agent in all the patients. Standard 12-lead (ECG) was evaluated before beginning of thrombolytic therapy (QTd 1) and 1 hour (QTd2) and 4 days (QTd3) after thrombolytic therapy. First, ECG was magnified × 10 for exact calculation of QT and QTd. After all, the variables were compared using one–way analysis of variance (ANOVA). Besides, P ≤ 0.05 was considered as statistically significant.

Results: This study was conducted on 160 patients. The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).

Conclusions: : Thrombolytic therapy had no significant effects on QTd. Thus, thrombolytic therapy does not increase the risk of arrhythmia.

Keywords

QT

Electrocardiography

Thrombolysis

Myocardial Infarction

Streptokinase

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