The Effects of 6 Isocaloric Meals on Body Weight, Lipid Profiles, Leptin, and Adiponectin in Overweight Subjects (BMI > 25)

Zeynab  Hatami Zargaran; Moosa&nbsp; &nbsp;Saleh; Seyed Taghi  Heydari; Siavash Babajafari

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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The Effects of 6 Isocaloric Meals on Body Weight, Lipid Profiles, Leptin, and Adiponectin in Overweight Subjects (BMI > 25)

Author(s):

Zeynab Hatami Zargaran¹,

Moosa   Saleh^1,*,

Seyed Taghi Heydari²,

Siavash Babajafari¹

1Research Center of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

2Research Center for Cardiovascular Atherosclerosis, Jahrom University of Medical Sciences, Jahrom, Iran

International Cardiovascular Research Journal:Vol. 8, issue 2; e12026

Published online:Jun 30, 2014

Article type:Research Article

Received:Apr 29, 2017

Accepted:Dec 31, 2013

How to Cite:Zeynab Hatami ZargaranMoosa   SalehSeyed Taghi HeydariSiavash BabajafariThe Effects of 6 Isocaloric Meals on Body Weight, Lipid Profiles, Leptin, and Adiponectin in Overweight Subjects (BMI > 25).Int Cardiovasc Res J.8(2):e12026.

Abstract

Background: It seems that meal frequency is negatively related to body weight, but the relationship between meal frequency and weight loss is not clearly known yet.

Objectives: The present study aimed to investigate whether 6 isocaloric meals affected body weight, lipid profiles, leptin, and adiponectin in overweight subjects.

Methods: The present randomized controlled trial was conducted on 90 overweight subjects in 3 months. The subjects were randomly divided into two groups. The control group continued their normal diet, while the intervention group was required to follow a 6 isocaloric meal diet instead of their previous meal pattern (3 meals and 2 snacks). The planned reduced calorie diets for both groups were identical, except for meal pattern. Blood samples were analyzed prior to and at the end of the study for total cholesterol, triglyceride, HDL-C, LDL-C, leptin, and adiponectinn concentrations. Paired t-test was used for comparison of the measurements before and after the study in each group. Besides, independent t-test was used for comparison of the measurements between the groups. P value less than 0.05 was considered as statistically significant.

Results: The mean age of the participants was 36.38 ± 9.7 in the intervention group and 37.6 ± 10.9 in the control group. In comparison to the control group, the intervention group showed a significant decrease in total cholesterol (P < 0.001), LDL-C (P < 0.001), BMI (P < 0.001), triglyceride (P < 0.001), and leptin (P = 0.002) and a significant increase in HDL (P < 0.001) and adiponectin (P = 0.031).

Conclusions: The 6 isocaloric meal pattern led to a reduction in BMI, lipid profiles (total cholesterol, LDL-C, triglyceride), and leptin concentrations and an increase in HDL and adiponectin compared to the normal diet.

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