Electrocardiography Changes in Children with Epileptic and Non-epileptic Seizures Compared to Controls

1Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, IR Iran

International Cardiovascular Research Journal:Vol. 16, issue 1; e120859

Published online:Mar 15, 2022

Article type:Research Article

Received:Nov 01, 2021

Accepted:Mar 15, 2022

How to Cite:Noormohammad NooriAlireza TeimouriAli Khajehelham shafighi shahriElectrocardiography Changes in Children with Epileptic and Non-epileptic Seizures Compared to Controls.16(1):e120859.

Abstract

Background: Epilepsy, febrile convulsion, and breath-holding spells are neurological diseases affecting the heart.

Objectives: This study aimed to evaluate electrocardiography alterations in children with epilepsy, febrile convulsion, and breath-holding spells compared to controls.

Methods: This case-control study was conducted on 360 children aged 0.5 - 5 years in Zahedan, Iran. The children with epilepsy, febrile convulsion, and breath-holding spells were diagnosed by a single neurologist based on the standard definition. Electrocardiography was also performed by a pediatric cardiologist. The data were analyzed using the SPSS 20.0 software, and P < 0.05 was considered statistically significant.

Results: Among the participants, 160 (44.4%) were female. Females also comprised 45.6%, 42.2%, 38.9%, and 51.1% of the participants in the epilepsy, febrile convulsion, breath-holding spells, and control groups, respectively. QTd was different in the epilepsy group compared to the controls and patients with breath-holding spells (P < 0.001). Additionally, QTc was significantly different in the epilepsy group in comparison to the controls (P < 0.001) and patients with breath-holding spells (P = 0.020), in the controls compared to the patients with febrile convulsion (P < 0.001), and in the controls in comparison to the patients with breath-holding spells (P < 0.001). QTcd was also different in the epilepsy group compared to the controls (P < 0.001), patients with breath-holding spells (P < 0.001), and those with febrile convulsion (P = 0.006) as well as in the controls in comparison with the patients with febrile convulsion and breath-holding spells (P < 0.001). Finally, QT was different in the patients with breath-holding spells compared to those with epilepsy (P = 0.005), in the patients with breath-holding spells in comparison with the controls (P = 0.002), and in the patients with breath-holding spells compared to those with febrile convulsion (P < 0.001).

Conclusions: The present study findings indicated that QT dispersion was different in the epilepsy group compared to the patients with breath-holding spells, corrected QT was different in the epilepsy group compared with the patients with breath-holding spells, QTc dispersion was different in the epilepsy group in comparison with the patients with breath-holding spells and febrile convulsion, and QT was different in the patients with breath-holding spells compared to those with epilepsy and febrile convulsion.

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