Association between Serum Iron and the Severity of Coronary Artery Disease

authors:

avatar Babak Bagheri 1 , * , avatar Mohammad Shokrzadeh 2 , avatar Vahid Mokhberi 1 , avatar Soheil Azizi 3 , avatar Alireza Khalilian 4 , avatar Negin Akbari 5 , avatar Valiallah Habibi 6 , avatar Keyvan Yousefnejad 1 , avatar Sasan Tabiban 1 , avatar Maryam Nabati 1

Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Department of Medical Technology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Department of Statistics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
International Cardiovascular Research Journal: Vol.7, issue 3; e12425
published online: September 30, 2013
article type: Research Article
received: May 03, 2017
accepted: June 12, 2013

how to cite: Bagheri B , Shokrzadeh M , Mokhberi V , Azizi S , Khalilian A , et al. Association between Serum Iron and the Severity of Coronary Artery Disease. Int Cardiovasc Res J. 2013;7(3):e12425. 

Abstract

Background: Coronary Artery Disease (CAD) is the most important cause of mortality in the world. About half of cardiovascular risk factors have not been completely understood. Oxidation of LDL by oxidants such as iron plays a central role in atherogenesis. As a result, evaluation of the iron stores is important in the risk evaluation of the atherosclerotic disease.
Materials and Methods: This cross sectional study was performed on 337 patients with chronic stable angina hospitalized in Sari heart center, Mazandaran University of Medical Sciences from February 2010 to July 2012. Coronary angiography was performed and the angiograms were evaluated by two cardiologists. Moreover, blood samples were collected after a 14-hour fast immediately before the coronary angiography in order to measure the total cholesterol, HDL- cholesterol, and glucose. The patients were divided into four groups to evaluate the severity of Coronary Artery Disease (CAD) according to Syntax scoring system.
Results: The study results revealed a significant difference among the four study groups regarding the iron serum level. It was significantly higher in the sever atherosclerosis group compared to the normal (P=0.0122), mild (P=0.023), and moderate CAD groups (P<0.001).
Conclusions: The findings indicated that the serum level of iron was higher in the atherosclerotic patients and increased with the severity of CAD. Therefore, a basic relationship probably exists between the serum iron level and CAD. Further prospective and experimental studies are needed to confirm the association between the iron status and atherosclerosis.

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References

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