Association between Serum Iron and the Severity of Coronary Artery Disease

Babak  Bagheri; Mohammad  Shokrzadeh; Vahid  Mokhberi; Soheil  Azizi; Alireza  Khalilian; Negin  Akbari; Valiallah  Habibi; Keyvan  Yousefnejad; Sasan  Tabiban; Maryam  Nabati

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Association between Serum Iron and the Severity of Coronary Artery Disease

Author(s):

Babak Bagheri^1,*,

Mohammad Shokrzadeh²,

Vahid Mokhberi¹,

Soheil Azizi³,

Alireza Khalilian⁴,

Negin Akbari⁵,

Valiallah Habibi⁶,

Keyvan Yousefnejad¹,

Sasan Tabiban¹,

Maryam Nabati¹

1Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

2Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

3Department of Medical Technology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

4Department of Statistics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

5Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran

6Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

International Cardiovascular Research Journal:Vol. 7, issue 3; e12425

Published online:Sep 30, 2013

Article type:Research Article

Received:May 03, 2017

Accepted:Jun 12, 2013

How to Cite:Babak BagheriMohammad ShokrzadehVahid MokhberiSoheil AziziAlireza KhalilianNegin AkbariValiallah HabibiKeyvan YousefnejadSasan TabibanMaryam Nabatiet al.Association between Serum Iron and the Severity of Coronary Artery Disease.Int Cardiovasc Res J.7(3):e12425.

Abstract

Background: Coronary Artery Disease (CAD) is the most important cause of mortality in the world. About half of cardiovascular risk factors have not been completely understood. Oxidation of LDL by oxidants such as iron plays a central role in atherogenesis. As a result, evaluation of the iron stores is important in the risk evaluation of the atherosclerotic disease.

Materials and Methods: This cross sectional study was performed on 337 patients with chronic stable angina hospitalized in Sari heart center, Mazandaran University of Medical Sciences from February 2010 to July 2012. Coronary angiography was performed and the angiograms were evaluated by two cardiologists. Moreover, blood samples were collected after a 14-hour fast immediately before the coronary angiography in order to measure the total cholesterol, HDL- cholesterol, and glucose. The patients were divided into four groups to evaluate the severity of Coronary Artery Disease (CAD) according to Syntax scoring system.

Results: The study results revealed a significant difference among the four study groups regarding the iron serum level. It was significantly higher in the sever atherosclerosis group compared to the normal (P=0.0122), mild (P=0.023), and moderate CAD groups (P<0.001).

Conclusions: The findings indicated that the serum level of iron was higher in the atherosclerotic patients and increased with the severity of CAD. Therefore, a basic relationship probably exists between the serum iron level and CAD. Further prospective and experimental studies are needed to confirm the association between the iron status and atherosclerosis.

Keywords

Coronary Artery Disease

Iron

Risk Factors

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