A Comparative Study on the Effect of Amiodarone and Metaprolol for Prevention of Arrythmias after Open Heart Surgery

Nayeem‑ ul‑hassan; Abdul  Majeed Dar; Mohd Lateef  Wani; Hilal Ahmad  Rather; Farooq Ahmad  Ganie

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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A Comparative Study on the Effect of Amiodarone and Metaprolol for Prevention of Arrythmias after Open Heart Surgery

Author(s):

Nayeem‑ ul‑hassan^1,*,

Abdul Majeed Dar¹,

Mohd Lateef Wani¹,

Hilal Ahmad Rather²,

Farooq Ahmad Ganie¹

1Department of Cardiovascular and Thoracic Surgery, Sher-i- Kashmir Institute of Medical Sciences, Soura Srinagar, Kashmir, India

2Department of Cardiology, Sher-i- Kashmir Institute of Medical Sciences, Soura Srinagar, Kashmir, India

International Cardiovascular Research Journal:Vol. 7, issue 1; e12711

Published online:Jun 30, 2017

Article type:Research Article

Received:May 07, 2017

Accepted:Feb 18, 2013

How to Cite:Nayeem‑ ul‑hassanAbdul Majeed DarMohd Lateef Wani Hilal Ahmad RatherFarooq Ahmad GanieA Comparative Study on the Effect of Amiodarone and Metaprolol for Prevention of Arrythmias after Open Heart Surgery.Int Cardiovasc Res J.7(1):e12711.

Abstract

Objectives: The aim of this study was to compare the effect of amiodarone and metaprolol in prevention of atrial fibrillation in patients, following open heart surgery.

Methods: This prospective study was carried out between May 2008 to Nov. 2010, and comprised a total of 50 patients with normal preoperative sinus rhythm undergoing open heart surgery using cardio pulmonary bypass.

Results: Mean age of patients was 47+2.7 years, of which 60% who developed atrial fibrillation aged from 51 to 60 years. Most patients (62%) were in NYHA Class III. Patients who received amiodarone showed significant improvement in LVEF compared to those treated with Metaprolol. Amiodarone treated group exhibited lesser incidence and short-lasting atrial fibrillation, lower ventricular rate, shorter hospitalization, and lesser cost of care than those in metaprolol group.

Conclusions: The present study showed that amiodarone was more efficient in controlling post-operative atrial fibrillation as compared to metaprolol. However, a larger randomized controlled trial is needed to corroborate the result of this study.

Keywords

Amiodarone

Metaprolol

Atrial Fibrillation

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