Right Ventricular Thrombus: A Rare Complication of Ovarian Hyperstimulation Syndrome


avatar Mahmood Zamirian 1 , * , avatar Alireza Moaref 1 , avatar Seyed Hosein Alavi 1 , avatar Khalil Zarrabi 1

Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

how to cite: Zamirian M, Moaref A , Alavi S H , Zarrabi K. Right Ventricular Thrombus: A Rare Complication of Ovarian Hyperstimulation Syndrome. Int Cardiovasc Res J. 2012;6(4):e12791. 


A 22 years old lady was admitted because of progressive dyspnea, severe abdominal
protrusion and lower extremity edema. She had undergone ovarian hyperstimulation
for primary infertility by Clomiphen and Human chorionic gonadotropin for 3 months.
Abdominopelvic ultrasonography revealed bilateral enlarged multi cystic ovaries and massive
ascites. Transesophageal echocardiography revealed a large thrombus in right ventrice apex.
Spiral chest CT scan showed normal pulmonary vasculature with no evidence of pulmonary
thromboembolism. Heparin was started and repeat echocardiographic study showed gradual
disappearance of right ventricular thrombus. Human chorionic gonadotropin is the most
important substance which leads to capillary leakage and fluid accumulation in third space.
Fluid shift and hypovolemia may cause hypotension, hemoconcentration and formation of
vascular thrombus.


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