A Comparative Study of Cardioprotective Effect of Three Anesthetic Agents by Measuring Serum Level of Troponin-T after Coronary Artery Bypass Grafting

Vali  Imantalab; Abbas Sedighinejad; Ali  Mir Mansouri; Alimohammad  Sadeghi Meibodi; Mohammad  Haghighi; Heidar  Dadkhah; Mohammadreza  Mobayen

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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A Comparative Study of Cardioprotective Effect of Three Anesthetic Agents by Measuring Serum Level of Troponin-T after Coronary Artery Bypass Grafting

Author(s):

Vali Imantalab¹,

Abbas Sedighinejad^1,*,

Ali Mir Mansouri¹,

Alimohammad Sadeghi Meibodi¹,

Mohammad Haghighi¹,

Heidar Dadkhah¹,

Mohammadreza Mobayen²

1Department of Cardiac anesthesia, Rasht University of Medical Sciences, Rasht, Iran

2Department of Burn Surgery, Motahari Burn Hospital, Rasht University of Medical Sciences, Tehran, Iran

International Cardiovascular Research Journal:Vol. 6, issue 3; e12797

Published online:Sep 30, 2012

Article type:Research Article

Received:May 09, 2017

Accepted:Jul 30, 2012

How to Cite:Vali ImantalabAbbas SedighinejadAli Mir MansouriAlimohammad Sadeghi MeibodiMohammad HaghighiHeidar DadkhahMohammadreza Mobayenet al.A Comparative Study of Cardioprotective Effect of Three Anesthetic Agents by Measuring Serum Level of Troponin-T after Coronary Artery Bypass Grafting.Int Cardiovasc Res J.6(3):e12797.

Abstract

Background: Cardiac surgery is associated with some degree of myocardial injury. Preconditioning first described in 1986 was pharmacologic and non- pharmacologic. Among the long list of anesthetic drugs, isoflurane as an inhaling agent along with midazolam and propofol as injectable substances have been documented to confer some preconditioning effects on myocardium.
Objectives: In this study cardiac Troponin T (cTnT) ,as a reliable marker, was used for evaluating myocardial injury.
Methods: This prospective double blind study was comprised of 60 patients scheduled for CABG and were randomly assigned into three groups who received infusion of propofol or midazolam or isoflorane. Surgical procedures and anesthetics were similar for 3 groups. cTnT measured preoperatively and at 12, 24 and 36hr after arrival in ICU.
Results: There were no statistically significant differences in mean cTnT levels between three groups in the preoperative period and 12-24 hours after arrival in ICU. However, mean cTnT in 3 groups at 36 hours after arrival in ICU were different (P< 0.013) and cTnT level was significantly higher in midazolam group (P<0.001) and lowest in isoflurane group (P=0.002).
Conclusion: There were significant differences on cTnT levels between anesthetic groups of isofluran, midazolam and propofol at 36 hr after surgery. Preconditioning effect of isoflurane was higher than the other two groups.

Keywords

Cardiac Surgery

Troponin T

Ischemia Preconditioning

Isoflurane

Propofol

Midazolam

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