The Perioperative Effect of Ascorbic Acid on Inflammatory Response in Coronary Artery Bypass Graft Surgery; A Randomized Controlled Trial Coronary Artery Bypass Graft Surgery

Reza  Jouybar; Hiva  Kabgani; Hamid  Kamalipour; Shahrbanoo  Shahbazi; Elaheh  Allahyary; Manoocher  Rasouli; Seyd Hedayatallah  Akhlagh; Masih  Shafa; Mohammad  Ghazinoor; Mohammad Taghi  Moeinvaziri; Saeed  Khademi

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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The Perioperative Effect of Ascorbic Acid on Inflammatory Response in Coronary Artery Bypass Graft Surgery; A Randomized Controlled Trial Coronary Artery Bypass Graft Surgery

Author(s):

Reza Jouybar¹,

Hiva Kabgani¹,

Hamid Kamalipour^2,*,

Shahrbanoo Shahbazi¹,

Elaheh Allahyary¹,

Manoocher Rasouli³,

Seyd Hedayatallah Akhlagh¹,

Masih Shafa¹,

Mohammad Ghazinoor¹,

Mohammad Taghi Moeinvaziri¹,

Saeed Khademi¹

1Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3Immunology and Clinical Microbiology Research center, Shiraz University of Medical Sciences, Shiraz, Iran

International Cardiovascular Research Journal:Vol. 6, issue 1; e12835

Published online:Sep 30, 2017

Article type:Research Article

Received:May 17, 2017

Accepted:Jan 14, 2012

How to Cite:Reza Jouybar, Hiva Kabgani, Hamid Kamalipour, Shahrbanoo Shahbazi, Elaheh Allahyary, et al. The Perioperative Effect of Ascorbic Acid on Inflammatory Response in Coronary Artery Bypass Graft Surgery; A Randomized Controlled Trial Coronary Artery Bypass Graft Surgery.Int Cardiovasc Res J.2017;6(1):e12835.

Abstract

Background: Different pharmacological agents may decrease the inflammatory response during cardiac surgery. The aim of this study was to evaluate the effect of ascorbic acid as an antioxidant on inflammatory markers (interleukins 6 and interleukin 8) released during cardiopulmonary bypass.

Method: Forty patients scheduled for elective coronary artery bypass grafting surgery, were randomly assigned to two groups. The patients in the case group were given 3 grams ascorbic acid 12-18 hours before operation and 3 grams during CPB initiation. The patients in the control group were given the same amounts of normal saline at similar times. Blood samples were collected 6 hours preoperatively and postoperative serum interleukin 6 and 8 were measured using enzyme-linked immunosorbent assay (ELISA).

Result: In both groups CPB caused an increase in IL6 and IL8 plasma concentrations compared with baseline levels, but the pattern of changes at such levels were similar in both groups after receiving ascorbic acid or placebo. Ascorbic acid did not reduce the inflammatory cytokines during CPB. Compared to the placebo, ascorbic acid had no significant effect on hemodynamic parameters such as systolic and diastolic blood pressure, heart rate, arterial blood gases, BUN, Creatinine and WBC and platelet counts.

Conclusion: Ascorbic acid has no effect on the reduction of IL6 and IL8 during CPB. Also, it causes no improvement in hemodynamics, blood gas variables, and the outcomes of patients undergoing CABG.

Keywords

Interleukin

Ascorbic Acid

Cardiopulmonary Bypass

Coronary Artery Bypass Grafting

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