Predictors and Prognosis of End-Stage Hypertrophic Cardiomyopathy

authors:

avatar Mohammad Ali Sadr Ameli ORCID 1 , avatar Azin Alizadehasl ORCID 2 , avatar Sheida Keshavari ORCID 3 , avatar Zohre Rahbar ORCID 3 , avatar Mahdi Khalili ORCID 4 , avatar Sepehr Jamalkhani ORCID 5 , avatar Zahra Shahidzadeh ORCID 4 , avatar Marzie Bazzi ORCID 4 , avatar Nima Sarisarraf ORCID 4 , avatar Masood Shekarchizadeh ORCID 4 , avatar Kamran Roudini ORCID 6 , avatar Rasoul Azarfarin 2 , avatar Robab Anbiaee ORCID 7 , avatar Maedeh Barahman ORCID 1 , avatar Zahra Hosseini ORCID 1 , avatar Davood Khoda-Amorzideh ORCID 2 , avatar Amir Abdi 8 , avatar Hooman Bakhshandeh 9 , avatar Alireza Ghavidel ORCID 10 , avatar Mina Mohseni 2 , avatar Zohre Kahe 3 , avatar Saideh Jamshidi ORCID 3 , *

Department of Interventional Cardiology, Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran
Cardio-oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran
Department of Echocardiography, Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
Cardiac Anesthesiology Department, Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran
Hematooncology Department, Tehran University of Medical Sciences, Tehran, IR Iran
Radio-Oncology Department, Shahid Beheshti University of Medical Science, Tehran, IR Iran
Islamic Azad University of Medical Sciences, IR Iran
Epidemiology Department, Iran University of Medical Sciences, Tehran, IR Iran
Heart Valve Disease Research Center, Rajaie Cardiovascular Medical & Research Center, Iran University of Medical Sciences, Tehran, IR Iran
International Cardiovascular Research Journal: Vol.16, issue 4; e130190
published online: December 31, 2022
article type: Research Article
received: July 03, 2022
revised: December 25, 2022
accepted: December 28, 2022

how to cite: Sadr Ameli M A, Alizadehasl A, Keshavari S, Rahbar Z, Khalili M, et al. Predictors and Prognosis of End-Stage Hypertrophic Cardiomyopathy. Int Cardiovasc Res J. 2022;16(4):e130190. 

Abstract

Background: Burned-out hypertrophic cardiomyopathy (BO-HCM) is complicated by substantial adverse events. However, few studies have focused on clinical or echocardiographic features and their prognostic values among patients with BO-HCM.

Objective: This study evaluated the clinical manifestations and prognostic value of echocardiography in patients with BO-HCM.

Methods: The present retrospective study evaluated 401 consecutive patients referred to the echocardiography ward of Rajaie Cardiovascular Center for evaluation of HCM during the period from January 2010 to February 2018. Three hundred six patients who completed the follow-up were included: 78 (25.4%) had BO-HCM and an EF of < 50% (group 1), and 228 (74.5%) had a normal EF in their baseline TTE (group 2). Among the group 2 population, 183 patients had a preserved EF of > 50% (group 2B), and 45 became BO-HCM at the end of their follow-up (group 2A). Clinical data were analyzed, including medical history, electrocardiography, and echocardiography. Generalized estimating equation (GEE) regression was performed to assess the association between patient characteristics and burned-out HCM.

Results: An atrial fibrillation (AF) rhythm was more common in the groups with BO-HCM (groups 1 and 2A) (32.8 vs. 14%; P = 0.002), as were Frequent premature ventricular contractions (PVCs) (13.98 vs. 5%; P = 0.040). Moderate or severe systolic anterior motion (SAM) was significantly more common in group 2B (LVEF > 50%) compared with group 1 and 2A, who had an EF of ≤ 50% (32.3% vs. 7.6%; P = 0.006). The S-wave of the right ventricle was significantly lower in groups 1 and 2A (9.73 vs. 11.8 cm/s; P < 0.001). Systolic pulmonary artery pressure (SPAP) was significantly higher in groups 1 and 2A (38.28 vs. 29.74 mmHg, P < 0.001). The differences in the prevalence of asymmetrical septal hypertrophy (ASH), left ventricular outlet (LVOT) obstruction, pericardial effusion (PE), diastolic dysfunction, and mitral regurgitation (MR) were insignificant between all groups.

 Conclusions: Among the patients suffering from HCM, the presence of AF rhythm, frequent PVCs, significant RV dysfunction, and absence of systolic anterior motion (SAM) of mitral valve leaflets have prognostic value and might be considered predictors for progression to BO-HCM.

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2023-10-04 12:43:04
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