Are Electrolyte Imbalances Related to 3-Month Outcomes in Patients with an Acute Myocardial Infarction? A Cohort Study from Iran

Salman Nikfarjam; Elham Ramezanzade; Yasaman Borghei; Bahare Gholami Chaboki; Baharak Alizadeh; Samaneh Karami; Arsalan Salari; Seyedeh Fatemeh Mirrazeghi

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Are Electrolyte Imbalances Related to 3-Month Outcomes in Patients with an Acute Myocardial Infarction? A Cohort Study from Iran

Author(s):

Salman Nikfarjam¹,

Elham Ramezanzade

²,

Yasaman Borghei¹,

Bahare Gholami Chaboki

¹,

Baharak Alizadeh¹,

Samaneh Karami¹,

Arsalan Salari

¹,

Seyedeh Fatemeh Mirrazeghi^1,*

1Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IR Iran

2Regenerative Medicine, Organ Procurement and Disciplinary Center, Razi Hospital, School Medicine, Guilan University of Medical Sciences, Rasht, IR Iran

International Cardiovascular Research Journal:Vol. 17, issue 2; e138445

Published online:Jun 30, 2023

Article type:Research Article

Accepted:Oct 04, 2023

How to Cite:Salman NikfarjamElham RamezanzadeYasaman BorgheiBahare Gholami ChabokiBaharak AlizadehSamaneh KaramiArsalan SalariSeyedeh Fatemeh Mirrazeghiet al.Are Electrolyte Imbalances Related to 3-Month Outcomes in Patients with an Acute Myocardial Infarction? A Cohort Study from Iran.Int Cardiovasc Res J.17(2):e138445.

Abstract

Background: Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Contradictory findings are available regarding the effects of changes in electrolytes in patients with an AMI.

Objectives: We aimed to investigate the effect of electrolyte changes on the 3-month outcome.

Methods: A total of 168 patients with AMI managed at Dr. Heshmat Hospital in Rasht, Iran, were investigated in this prospective cohort study by a census method. AMI was confirmed by biochemical, electrocardiographic, or angiographic evidence. Electrolyte serum levels, demographic characteristics, myocardial infarction type, ejection fraction (EF), and underlying diseases were collected in a checklist in the early hours after each patient entered the hospital. Information about patients' outcomes and echocardiographic data were collected after three months. All data were analyzed using SPSS software version 22.

Results: Out of 162 patients with AMI, most (44%) were aged between 50 to 59 years, and 76.8% were men. In all models, the odds of non-recovery remained constant with increasing electrolytes. On uni-variable and multi-variable models, sodium showed a significant positive association with initial EF (unstandardized coefficient = 0.8 in both uni-variable and multi-variable models, approximately), and phosphorus displayed a significant negative association with initial EF (unstandardized coefficient = -4.5 in both uni-variable and multi-variable models, approximately). There was no significant association of electrolytes with follow-up EF in all models.

Conclusions: In this study, the phosphorus and sodium serum levels were significantly related to the initial EF. However, none of the studied electrolytes impacted the 3-month outcome in AMI patients.

Keywords

Potassium

Phosphorus

Sodium

Acute Myocardial Infarction

Magnesium

Electrolytes

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