Roles of Serum Parathyroid Hormone and Vitamin D Levels in Severity of Coronary Artery Disease and Left Ventricular Systolic Function

1Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IR Iran

International Cardiovascular Research Journal:Vol. 17, issue 2; e139878

Published online:Dec 25, 2023

Article type:Research Article

How to Cite:Arsalan SalariArash MazouriYasaman BorgheiSamaneh KaramiJalal KheirkhahFardin Mirbolouket al.Roles of Serum Parathyroid Hormone and Vitamin D Levels in Severity of Coronary Artery Disease and Left Ventricular Systolic Function.Int Cardiovasc Res J.17(2):e139878.

Abstract

Background: Vitamin D and parathyroid hormone (PTH) are related but impact cardiovascular functions differently.

Objectives: This study investigated the roles of PTH and vitamin D serum levels in the severity of coronary artery disease and left ventricular systolic function (LVSF).

Methods: This cross-sectional study was conducted on 271 participants who underwent elective coronary angiography at Dr. Heshmat Hospital, selected by convenience sampling over four months. 25-hydroxyvitamin D (25 (OH) D) and PTH levels were obtained from patients’ blood samples. Vitamin D levels were categorized into three categories. The SYNTAX score was used to evaluate the severity of coronary artery disease (CAD), classified across three categories. The chi-squared test, independent samples t-test, and multivariable logistic regression were used for statistical analysis. Data were analyzed by SPSS ver.21.

Results: Diabetes, hypertension, dyslipidemia, and lower vitamin D levels were independent variables affecting patients’ high-risk conditions. The highest SYNTAX score was in patients with vitamin D deficiency (P < 0.001). Patients with different ejection fractions did not have statistically significant differences in vitamin D (25.38 ± 14.23) and PTH levels (66.62 ± 17.39) (P = 0.4). The severity of CAD in patients with PTH > 40 was higher than in patients with PTH ≤ 40, but this was not statistically significant (P = 0.06).

Conclusion: Our results showed an inverse relation between CAD and vitamin D. However, the CAD risk did not change with PTH levels.

Keywords

Cardiovascular Diseases

parathyroid hormone

Left Ventricular Systolic Function

25-Hydroxyvitamin D

Coronary Artery Disease

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