Effect of Acute Smoking on Diastolic Function

ME  Ghaidari; Mohammad Ali Akbarzadeh; Sh  Yazdani; Mohammad Asadpour Pirnfar; Amir Aslani

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Effect of Acute Smoking on Diastolic Function

Author(s):

ME Ghaidari¹,

Mohammad Ali Akbarzadeh^1,*,

Sh Yazdani¹,

Mohammad Asadpour Pirnfar¹,

Amir Aslani²

1Cardiology department, Taleghani hospital, Shaheed Beheshti Medical University, Iran

2Department of Pacemaker and Electrophysiology, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran,, Iran

International Cardiovascular Research Journal:Vol. 4, issue 2; e65016

Published online:Jun 30, 2010

Article type:Research Article

Received:Dec 17, 2017

Accepted:Jun 30, 2010

How to Cite:ME GhaidariMohammad Ali AkbarzadehSh YazdaniMohammad Asadpour PirnfarAmir AslaniEffect of Acute Smoking on Diastolic Function.Int Cardiovasc Res J.4(2):e65016.

Abstract

Background: Smoking is a known risk factor of atherosclerosis, endothelial dysfunction, athermanous plaque
rupture, unstable coronary syndrome and sudden cardiac death.
Methods: The present study comprised 40 randomly selected healthy male hospital staff without a history of hypertension
or cardiac or pulmonary disease. Participants were divided into two groups. The first group included
20 professional smokers (at least 5 pack/year till the time of study) and the second group consisted of 20 nonprofessional
smokers defined as 0.5 pack/ year or less till the time of study. Participants were instructed not to
smoke for 6 hours before the study. Patients underwent echocardiography before smoking. The participants were
then asked to smoke a whole cigarette. After smoking, echocardiography was repeated within 7 to 15 minutes.
Echocardiographic indices of diastolic function (E wave, A wave, Ea, E/A ratio and deceleration time) were
measured before and after smoking.
Results: There was no statistically significant difference in the baseline measures in both groups before smoking
and also there was no significant difference between measures in the two groups after smoking. The analysis of
the pooled data from two groups showed that, smoking resulted in significant increase of heart rate (P<0.001).
A wave, E wave, Ea, E/A ratio and deceleration time changed significantly after smoking (P<0.001, P=0.027,
P=0.011, P<0.001 and P<0.001 respectively).
Conclusion: Smoking of only a cigarette in both professional and nonprofessional smokers, resulted in the same
significant diastolic dysfunction.

Keywords

Smoking

Diastolic Function

Echocardiography

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