A survey on structural and functional cardiac abnormalities in transfusion dependent thalassemia, a report from the south-east of Iran

Ali Bazi; Iraj Shahramian; mojtaba delaramnasab; Nosratollah Masinaeenezhad; Zohre Mahmoodi; Ali Khosravi-Bonjar; Amin Safa

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards & Committees Indexing and Listing Sources Journal Metrics Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

A survey on structural and functional cardiac abnormalities in transfusion dependent thalassemia, a report from the south-east of Iran

Author(s):

Ali Bazi¹,

Iraj Shahramian²,

mojtaba delaramnasab¹,

Nosratollah Masinaeenezhad³,

Zohre Mahmoodi⁴,

Ali Khosravi-Bonjar³,

Amin Safa^3,*

1Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran

2Pediatric Ward, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran

3Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, Iran

4Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran

International Cardiovascular Research Journal:Vol. 12, issue 3; e67339

Published online:Sep 01, 2018

Article type:Research Article

Received:Aug 27, 2018

Accepted:Jun 10, 2018

How to Cite:Bazi A, Shahramian I, delaramnasab M, Masinaeenezhad N, Mahmoodi Z, et al. A survey on structural and functional cardiac abnormalities in transfusion dependent thalassemia, a report from the south-east of Iran. Int Cardiovasc Res J. 2018;12(3):e67339. doi:

Abstract

Background:

Cardiac abnormalities are common complications in Transfusion Dependent Thalassemia (TDT).

Objectives:

This study aimed to assess functional and structural cardiac abnormalities in TDT patients in Zabol, Sistan and Baluchistan province in south-east of Iran.

Patients and Methods:

This cross-sectional study was conducted on 85 TDT patients selected via simple random sampling. Demographic information was obtained using a questionnaire. Additionally, clinical and laboratory data were extracted from medical records. Cardiac assessment was conducted by standard Doppler echocardiography. After all, the data was statistically analyzed using the SPSS statistical software, version 19.

Results:

In this study, 54 participants (63.5%) were female and 31 ones (36.5%) were male. The participants’ mean age was 19.2 ± 6.1 years. In addition, 58 patients (68.2%) had at least one cardiac abnormality. The mean of Left Ventricular Ejection Fraction (LVEF) was 60.3 ± 8.5% (range: 40 - 80%). The most common cardiac conditions were Tricuspid Regurgitation (TR) (58.8%), Left Ventricular Diastolic Dysfunction (LVDD) (43.5%), Pulmonary valve Insufficiency (PI) (35.3%), and Mitral Regurgitation (MR) (32.9%). Moreover, Left Ventricular Systolic Dysfunction (LVSD), Aortic Insufficiency (AI), and pericard effusion were detected in 6 (7.1%), 2 (2.4%), and 2 patients (2.4%), respectively. The results revealed a significant association between LVDD and splenomegaly, splenectomy, hepatomegaly, chelation therapy, and anti-HCV positivity. Indeed, anti-HCV positivity was significantly associated with MR and lower LVEF. Patients with positive anti-HCV results presented a higher risk of cardiac dysfunction (OR = 4.1, 95% CI: 0.8 - 19.8, P = 0.022) and LVEF < 55% (OR = 4.2, 95% CI: 1.2 - 14.9, P = 0.027).

Conclusions:

The results indicated anti-HCV positivity as a significant risk factor for heart dysfunction in TDT patients. Thus, cardiac functionality is recommended to be assessed regularly in TDT patients.

Keywords

Heart

Thalassemia

Mitral Valve Insufficiency

Hepatitis C

Fulltext

The full text is available in PDF.

References

1.
The references are available in PDF.

Import into EndNote Import into BibTex

Indexed in

Scopus

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 3 weeks ago
Scopus by Title: 0
Last Update: 3 weeks ago
Scopus by Title (Ref): 1
Last Update: 3 weeks ago
CrossRef: 0
Last Update: 6 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Ali Bazi:[PubMed][Scholar]
Iraj Shahramian:[PubMed][Scholar]
mojtaba delaramnasab:[PubMed][Scholar]
Nosratollah Masinaeenezhad:[PubMed][Scholar]
Zohre Mahmoodi:[PubMed][Scholar]
Ali Khosravi-Bonjar:[PubMed][Scholar]
Amin Safa:[PubMed][Scholar]

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Outlines

A survey on structural and functional cardiac abnormalities in transfusion dependent thalassemia, a report from the south-east of Iran

Abstract

Fulltext

References

Last Update: 3 weeks ago

Last Update: 3 weeks ago

Last Update: 3 weeks ago

Last Update: 6 days ago