Predictive Value of Cardiovascular Risk Factors for Risk Assessment in Cohort of Shiraz Heart Study

M  Fathzadeh; Mohammad Javad  Zibaeenezhad; MA  Babaee Bigi; Shahdad Khosropanah; Mahmood Zamirian; Kamran Aghasadeghi; Alireza  Moaref; Firoozeh  Abtahi; Seyed Taghi  Heydari; Mohammad Hassan Eftekhari

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Predictive Value of Cardiovascular Risk Factors for Risk Assessment in Cohort of Shiraz Heart Study

Author(s):

M Fathzadeh^1,*,

Mohammad Javad Zibaeenezhad²,

MA Babaee Bigi¹,

Shahdad Khosropanah¹,

Mahmood Zamirian³,

Kamran Aghasadeghi¹,

Alireza Moaref¹,

Firoozeh Abtahi⁴,

Seyed Taghi Heydari¹,

Mohammad Hassan Eftekhari¹

2Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Shiraz, Iran

3Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4cardiology, cardiovascular research center, shiraz university of medical sciences, shiraz, Iran

International Cardiovascular Research Journal:Vol. 4, issue 1; e67646

Published online:Mar 30, 2010

Article type:Research Article

Received:Feb 19, 2010

Accepted:Mar 31, 2010

How to Cite:M FathzadehMohammad Javad ZibaeenezhadMA Babaee BigiShahdad KhosropanahMahmood ZamirianKamran AghasadeghiAlireza MoarefFiroozeh AbtahiSeyed Taghi HeydariMohammad Hassan Eftekhariet al.Predictive Value of Cardiovascular Risk Factors for Risk Assessment in Cohort of Shiraz Heart Study.Int Cardiovasc Res J.4(1):e67646.

Abstract

Background: Risk assessment for fast growing burden of cardiovascular diseases is very important and difficult.
As a response to this challenge, in particular, genetic risk factors which potentially modify risk, we conducted
a survey of primary data registry of Shiraz Heart Study on integration and application of family history
data in prevention of cardiovascular disorders.
Method: This study is a longitudinal cohort project to be extended from subpopulations of different job groups
to the community.
Results: Parental family history of MI, diabetes mellitus (DM), hyperlipidemia (HPL), hypertension (HTN) was
reported more frequently among females than males. Histories of MI, DM, HPL, and HTN in both parents were
respectively positive in 2.6%, 2%, 4.6%, and 7.9 % of the participants. Odd ratios (OR) for risk of MI from family
history of MI were 2.7; risk of DM from family history of DM 4.5; risk of HPL from family history of HPL
2.04; and risk of HTN from family history HTN 4.7. Also, family history of MI modifies risk of HPL (OR=1.7,
P<0.0001); and family history of DM modifies risk of HPL (OR=2.04, P<0.0001).
Conclusion: Our primary result shows potent application of family history data in risk assessment of cardiovascular
outcome. In particular, HTN appears as a silent and leading risk modifier. In regard to the course of
continuing Shiraz Heart Study integration of family history of risk factors crucial in public health we suggest to
adopt a network of electronic health records from the “Health House” to the “Heart House”.

Keywords

Myocardial Infarction

Family History

Risk Assessment

Cohort Study

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References

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