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Relationship Between Periodontal Disease and Acute Myocardial Infarction


avatar Mahmood Zamirian 1 , * , avatar S Raoofi 2 , avatar Shahdad Khosropanah 2 , avatar R Javanmardi 2

1 Department of cardiology, cardiovascular research center, Iran

2 Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

How to Cite: Zamirian M, Raoofi S , Khosropanah S, Javanmardi R . Relationship Between Periodontal Disease and Acute Myocardial Infarction. Int Cardio Res J. 2007;1(4):e69667.


International Cardiovascular Research Journal: 1 (4); e69667
Published Online: December 31, 2007
Article Type: Research Article
Received: April 24, 2018
Accepted: December 31, 2007


Background: Conventional risk factors for coronary artery disease and myocardial infarction do not explain all
of the clinical and epidemiological features of the disease. Periodontal disease is a common bacterial and destructive
disorder of oral tissues. Many studies demonstrate close association between chronic periodontitis and
development of generalized inflammation, vascular endothelial injury, and atherosclesis.
Periodontal disease has been convincingly emerging as an important independent risk factor for ischemic heart
disease. A case - control study was carried out to assess the prevalence of periodontitis in patients with Acute
myocardial Infarction (AMI) and evaluate the possible relationship between AMI and chronic periodontitis.
Patients and Methods: A number of 160 patients, aged 35 to 70 years old, enrolled in the study. Eighty patients
(43 men, 37 women) were examined four days after hospitalization due to AMI. Control group consisted of 80
persons (38 men, 42 women) with normal coronary angiography. The following periodontal parameters were
examined: Plaque index (PI), gingiral index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment
loss (CAL) and number of sites with CAL.
Results: The case, compared to control showed significantly worse results for some periodontal variables studied:
The mean of PD and PD > 3 mm, CAL, and number of sites with CAL, had worse results compared to control
despite similar oral hygiene and frequency of brushing. The confounding factors for the present study were found
to be hypertension and diabetes.
Conclusion: The association between periodontitis and acute myocardial infarction was significant after adjusting
for conventional risk factors for AMI.


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© 2007, Shiraz University of Medical Sciences.