Predictive Value of a Zero Coronary Artery Calcium Score in Major Adverse Cardiac Events in Old Age

Anita Sadeghpour; Mehrdad Azimi; Hamid Reza Pouraliakbar; Majid Kyavar; Azin Alizadehasl; Hossein Nazari Hayanou; Reza Hajizadeh

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Predictive Value of a Zero Coronary Artery Calcium Score in Major Adverse Cardiac Events in Old Age

Author(s):

Anita Sadeghpour

¹,

Mehrdad Azimi

¹,

Hamid Reza Pouraliakbar

¹,

Majid Kyavar

²,

Azin Alizadehasl

¹,

Hossein Nazari Hayanou

³,

Reza Hajizadeh

^4,*

1Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

2Cardiovascular intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

3Echocardiography Lab, Department of Cardiology, Imam Reza International University, Mashhad, IR Iran

4Department of Cardiology, Urmia University of Medical Sciences, Urmia, IR Iran

International Cardiovascular Research Journal:Vol. 13, issue 3; e88459

Published online:Sep 01, 2019

Article type:Research Article

Received:Dec 30, 2018

Accepted:Jul 20, 2019

How to Cite:Anita SadeghpourMehrdad AzimiHamid Reza PouraliakbarMajid KyavarAzin AlizadehaslHossein Nazari HayanouReza Hajizadehet al.Predictive Value of a Zero Coronary Artery Calcium Score in Major Adverse Cardiac Events in Old Age.Int Cardiovasc Res J.13(3):e88459.

Abstract

Background:

By estimating the total coronary plaque burden, the Coronary Artery Calcium (CAC) score determines the risk of Coronary Artery Disease (CAD). The presence of a zero CAC score may be highly predictive of very low risk patients for Major Cardiac Adverse Events (MACEs) due to its close relation with the severity of CAD.

Objective:

The present study aimed to evaluate the value of a zero CAC score for predicting MACEs in patients older than 60 years suspected of CAD.

Methods:

Between April 2011 and March 2012, 128 patients aged > 60 years with a zero CAC score on admission without a previous history of CAD were consecutively included in this study with a mean follow-up period of 45.7 months. The continuous variables were compared using t-test or Mann–Whitney U test and the categorical ones were compared using chi-square test. The statistical analyses were done using the SPSS statistical software, version 23.0.

Results: This study was conducted on 128 patients (35 males and 93 females). The incidence of MACEs was 2.3% in a mean follow-up period of 45.7 months and 0.6 per 100 patient-years. Additionally, the MACE-free survival rates were 99.1%, 99.1%, and 87.7% in one, three, and five years, respectively. The negative predictive value of a zero CAC score for predicting long-term MACEs was 100% in the patients older than 70 years and 96.8% in those aged between 60 and 70 years. No cardiac-related death was recorded within the follow-up period.

Conclusion: A zero CAC score had a high negative predictive value for predicting long-term MACEs in elderly patients with mild to moderate pretest probability of CAD, which reached 100% among the patients older than 70 years.

Keywords

Computed Tomography Angiography

Aging

Coronary Artery Disease

Calcium Scoring

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