Abstract
Background: There are several lines of evidence which indicates the involvement of Hippocampus and dopaminergic system in different types of learning and memory. Objective: To determine the effect of Dopamin system on spatial learning and rhythmic slow activity (RSA) of the hip. Methods: In one group of rats VTA was lesioned bilaterally by ICV injection of 6-OHDA. In two other groups, SCH (0.05 mg/kg.IP) and sulfirid (50 mg/kg.IP) was injected. A pair of electrode was implaned in dorsal hip of the rat. Findings: In the control group, the rats reached the learning criteria at the 14th session and frequency and duration of RSA to non-RSA increased as learning session progressed. Dopaminergic chemical lesioning of VTA with 6-OHDA impaired spatial learning but had no significant effect on RSA. Injection of Dopamin antagonist impared acquisition and also decreased the frequency of RSA and ratio of RSA to non RSA on the injection day. Conclusion: The dopaminergic system has a modulatory effect on RSA of hip and spatial learning.
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