Journal of Inflammatory Diseases
The Official Journal of Qazvin University of Medical Sciences
Effects of reversible inactivation of bilateral basolateral Amygdala area on memory storage in rat
Authors
Abstract
Background: Basolateral Amygdala area has a major role in the retention of passive avoidance learning. Objective: To determine the effects of reversible inactivation of bilateral basolateral Amygdala area on memory storage in rat. Methods: Male wistar rats were surgically implanted bilaterally with cannulae at the BLA. One week later they received one trial PAL (1 mA 1.5 S) and immediately on 60, 90 and 120 min after posttraining, lidocaine was infused into the BLA. Retention was tested two days after training. Findings: Findings indicated a significant impaired retention performance 60 and 90 minutes after posttraining infusion of lidocaine into the BLA. Infusion administered 120 minutes after training had no effect. Conclusion: The time-dependent retrograde impairment of memory produced by posttraining reversible inactivation of the BLA suggests that this region of the amygdala is involved in the consolidation and storage of memory for PA
Highlights
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Similar Articles
Effects of activation and inactivation of glucocorticoid receptors of basolateral amygdala on fear memory extinction in rats
Omoumi S, Rashidy-Pour AL, Shafiee M, Vafaei AA. Effects of activation and inactivation of glucocorticoid receptors of basolateral amygdala on fear memory extinction in rats. koomesh. 2014;15(3):e153884. doi:
Influence of basolateral amygdala lesion on the inhibitory effects of propranolol on voluntary exercise- induced enhancement of learning and memory
Ebrahimi S, Rashidy-Pour A, Vafaei AA, MohammadAkhavan M, Haghighi S. Influence of basolateral amygdala lesion on the inhibitory effects of propranolol on voluntary exercise- induced enhancement of learning and memory. koomesh. 2010;11(2):e152276. doi:
The effect s of muscimol injection into basolateral amygdala on spatial memory processing in place avoidance learning task
RashidiPor A, Vafaei AA. The effect s of muscimol injection into basolateral amygdala on spatial memory processing in place avoidance learning task. koomesh. 2001;2(2):e151921. doi:
The Effect of Memantine Administration on Anxiety Maintenance in Stressed Male Wistar Rats
Rafia A, Oryan S, Sahraei H, Eidi A. The Effect of Memantine Administration on Anxiety Maintenance in Stressed Male Wistar Rats. Iran J Psychiatry Behav Sci. 2019;13(4):e89526. doi: https://doi.org/10.5812/ijpbs.89526
Comparison of the Effects of Deep Brain Stimulation of the Prelimbic Cortex and Basolateral Amygdala for Facilitation of Extinction Process of Conditioned Fear
Mokhtari Hashtjini M, Pirzad Jahromi G, Sadr SS, Khaleghi A, Hatef B, et al. Comparison of the Effects of Deep Brain Stimulation of the Prelimbic Cortex and Basolateral Amygdala for Facilitation of Extinction Process of Conditioned Fear. Arch Neurosci. 2020;7(4):e101743. doi: https://doi.org/10.5812/ans.101743
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 0
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 3 days ago
- OpenAlex: 0
Last Update: 14 hours ago
- OpenCitations: 0
Last Update: 11 hours ago