Abstract
Background: Basolateral Amygdala area has a major role in the retention of passive avoidance learning. Objective: To determine the effects of reversible inactivation of bilateral basolateral Amygdala area on memory storage in rat. Methods: Male wistar rats were surgically implanted bilaterally with cannulae at the BLA. One week later they received one trial PAL (1 mA 1.5 S) and immediately on 60, 90 and 120 min after posttraining, lidocaine was infused into the BLA. Retention was tested two days after training. Findings: Findings indicated a significant impaired retention performance 60 and 90 minutes after posttraining infusion of lidocaine into the BLA. Infusion administered 120 minutes after training had no effect. Conclusion: The time-dependent retrograde impairment of memory produced by posttraining reversible inactivation of the BLA suggests that this region of the amygdala is involved in the consolidation and storage of memory for PA
Keywords
Basolateral amygdala area (BLA) Passive avoidance learning (PAL) Reversible inactivation Memory
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.