Antibody response to Streptokinase

A Afshari; E Holme; S Hillis

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Antibody response to Streptokinase

Author(s):

A Afshari,

E Holme^,*,

S Hillis

Journal of Inflammatory Diseases:Vol. 4, issue 3; 8-13

Article type:Research Article

How to Cite:A AfshariE HolmeS HillisAntibody response to Streptokinase.J Inflamm Dis.4(3):e154721.

Abstract

Abstract Background: Streptokinase is administered during acute myocardial infarction (AMI). It is prepared from beta haemolytic streptococci and in some cases pre-existing antibodies may compromise the use of streptokinase. Objective: To study levels of anti-streptokinase antibodies in AMI patients during thrombolytic therapy. Methods: Specific IgG, IgA, IgM and anti-streptokinase antibodies (ELISA) were studied in 246 cases. Pre and post-therapy levels of these antibodies were examined in 10 cases given streptokinase for AMI. Findings: Neutralizing anti-streptokinase were detectable in 61.7% of the controls which 0.43% of them had levels above the normal range. Neutralizing anti-streptokinase antibodies showed a positive correlation with the level of IgG anti-streptokinase antibodies (r=+0.55, P

Keywords

Keywords: Streptokinase

Acute myocardial infarction (AMI)

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