Abstract
Background: Vasogenic brain edema disturbs blood brain barrier and consequently increase intracranial pressure. It may also affect CSF electrolytes concentrations and brain blood flow. Objective: To compare the CSF osmolality and carotid blood flow in normal and brain edema conditions in rabbits. Methods: 6 groups of rabbits were studied in which 3 groups had normal carotid blood flow and in the other 3, the vasogenic brain edema was obtained by ligation of common carotid arteries. The osmolality of CSF and carotid blood flow were determined and compared with normal determination. Pathological and radiological investigations were also determined. Findings: Brain edema was confirmed with CT Scan and pathological findings. The osmolality of CSF in brain edema and normal conditions were 290.9±7.6 and 296±5.73 mosmole/kg and carotid brain flow were 6.77±0.24 and 7.83±1.09 ml/min respectively. No significant difference between normal and edema conditions were observed. Conclusion: The reduction of brain blood flow in brain edema may compensate with increase of systemic blood pressure. The CSF osmolality did not change during brain edema.
Keywords
Brain edema Cerebrospinal fluid (CSF) Carotid blood flow Rabbit
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.