Comparison of urinary Neopterin to Creatinin ratio in Multiple Sclerosis patients and controlled group

H Khorrami; M Kadkhodaei; J Lotfi; MR Eshraghian; A Ahadi; F Amiri; T Neyestani

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Comparison of urinary Neopterin to Creatinin ratio in Multiple Sclerosis patients and controlled group

Author(s):

H Khorrami,

M Kadkhodaei^,*,

J Lotfi,

MR Eshraghian,

A Ahadi,

F Amiri,

T Neyestani

Journal of Inflammatory Diseases:Vol. 6, issue 3; 12-17

Article type:Research Article

How to Cite:H KhorramiM KadkhodaeiJ LotfiMR EshraghianA AhadiF AmiriT Neyestaniet al.Comparison of urinary Neopterin to Creatinin ratio in Multiple Sclerosis patients and controlled group.J Inflamm Dis.6(3):e154884.

Abstract

Abstract Background: Multiple Sclerosis as the most common cause of demyelinating disorders and has a basis of autoimmunity. Objective: To describe a procedure to determine total and aromatic UNCR and their ratio as a marker of cell mediated immunity in MS patients and controlled groups. Methods: In this project UNCR was determined and compared in MS patients who referred to the neurology department of Shariati's Hospital and normal subjects using HPLC and Novapak C18 (3.9x300mm) column at 25 degrees centigrade. Findings: Mean of aromatic UNCR were 337.6±47.2 and 1273.1±201.64 micromol/mol, mean of total UNCR were 484.64±60.2 and 1800.3±250.1 micromol/mol, and the ratio of aromatic/total UNCR were 0.664 and 0.73 in normal subjects and MS patients respectively. Conclusion: Prominent elevation of aromatic UNCR in MS patients in comparison with normal subjects is the sign of high activity of cell-mediated immunity in this group even though with treatment.

Keywords

Keywords: Urinary neopterin to creatinin ratio (UNCR)

Multiple sclerosis (MS)

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