Abstract
Abstract
Background: Multiple Sclerosis as the most common cause of demyelinating disorders and has a basis of autoimmunity.
Objective: To describe a procedure to determine total and aromatic UNCR and their ratio as a marker of cell mediated immunity in MS patients and controlled groups.
Methods: In this project UNCR was determined and compared in MS patients who referred to the neurology department of Shariati's Hospital and normal subjects using HPLC and Novapak C18 (3.9x300mm) column at 25 degrees centigrade.
Findings: Mean of aromatic UNCR were 337.6±47.2 and 1273.1±201.64 micromol/mol, mean of total UNCR were 484.64±60.2 and 1800.3±250.1 micromol/mol, and the ratio of aromatic/total UNCR were 0.664 and 0.73 in normal subjects and MS patients respectively.
Conclusion: Prominent elevation of aromatic UNCR in MS patients in comparison with normal subjects is the sign of high activity of cell-mediated immunity in this group even though with treatment.
Keywords
Keywords: Urinary neopterin to creatinin ratio (UNCR) Multiple sclerosis (MS)
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.