The effect of sucralfate suspension on recurrent aphthous stomatitis

Abstract Background: Recurrent aphthous stomatitis (RAS) is one of the most common diseases of oral cavity which affects 10-20 % of normal population . It vastly affects the patient's nutrition, oral hygiene and social communication. Objective: To determine the effect of sucralfate suspension on RAS treatment. Methods: In this double blined clinical trial, 78 patients with RAS (aged 15-57 years old) were studied: group A received sucralfate suspension and group B received a similar suspension without sucralfate as a mouthwash, for one minute three times a day each. Findings: There was no difference in the time of pain reduction in both groups (P>0.05). On 7th days of treatment , 24 patients of group A and 15 patients of group B (P<=0.05 - P=0.035) & after 14 days 38 patients of group A and 31 of group B had complete remission (P= 0.014). It was a significant difference. Rebound of lesion after 3 months was 5 in group A and 8 in group B which was not significant. Conclusion: The sucralfate suspension is more effective in treating aphthous stomatitis.