Abstract
Abstract
Background: Sleeping is a biological rhythm controlled by many structures and neurotransmitter systems in brain. Previous evidences suggested that Orbitofrontal Cortex (OFC) is probably involved in sleeping time and the duration.
Objective: The aim of this study was to determine the role of OFC area in duration and the time of sleeping by electrical lesions.
Methods: Male Wistar rats were used in this experimental study. Rats were surgically implanted bilaterally guided cannulae aimed at the OFC by stereotaxic instrument. One week after recovery, a primary assessment of sleeping duration was made by Angel behavioral method followed by lesioning of OFC using a lesion-maker (electrical electrode). Measuring the behavioral manifestations continued for time and the sleeping duration.
Findings: The data found in our study was indicative of a significantly increased sleeping time (P<0.01) following the electrical lesioning of OFC.
Conclusion: Our findings showed that OFC of rat’s brain may play an important role in regulating the sleeping process.
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Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.