Comparing the effects of Fluoxetine and Alprazolam on blood glucose in patients with type 2 diabetes

How to Cite:M Afkhami ArdekaniA Shojaoddini ArdekaniV SoltaniE MolanooriComparing the effects of Fluoxetine and Alprazolam on blood glucose in patients with type 2 diabetes.J Inflamm Dis.12(1):e155373.

Abstract

¯Abstract Background: Diabetes mellitus is the most common endocrine disorder causing micro- and macrovascular complications which could be prevented by good glycemic control. Considering many patients who become resistant to routine anti-diabetic drugs after few years, the administration of other drugs to reduce the level of glucose is an essential approach for a better glycemic control. Objective: The aim of this study was to compare the effects of fluoxetine and alprazolam added to regular anti-diabetic drugs on blood glucose in patients with type 2 diabetes. Methods: In this paralleled clinical trial, 66 uncontrolled type 2 diabetic patients referred to Yazd Diabetes Research Center were selected and received randomly either 20mg of fluoxetine or 0.5mg of alprazolam for 6 weeks. Mean FBS (fasting blood sugar), 2hpp (2 hours post-prandial glucose), HbA1c (Glycated Hemoglobin) and BMI (Body Mass Index) were measured before and after the study. Data were analyzed by t-test and paired t-test. Findings: The mean FBS, 2hpp, HbA1c and BMI were decreased after using fluoxetine by 27.5±7.5mg/dl, 47.5±10.5, 1.5±0.5% and 2.2±0.8kg/m2, respectively (P=0.001). Also the mean FBS, 2hpp and HbA1c were decreased by 13.7±13.5mg/dl, 22.5±5.6mg/dl and 0.5±0.3% following the administration of alprazolam (P=0.001). Similarly,, the mean BMI was increased by 0.3±1.5 kg/m2 this difference was found to be statistically insignificant (P=0.35). Conclusion: Both fluoxetine and alprazolam were useful for better control of blood glucose in diabetics who were free of diabetic complications nevertheless, it seems that fluoxetine is more effective than alprazolam

Keywords

Keywords: Fluoxetine

Alprazolam

Blood Glucose

Type2 Diabetes Mellitus

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