Investigation of insulin resistance in patients with liver cirrhosis and its relationship with severity of disease

A Gharavi; AA Hajagha Mohammadi; A Ziaee; MR Sarookhani; A Javadi; S Haghazali

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

Authors Guide Submit Manuscript

Investigation of insulin resistance in patients with liver cirrhosis and its relationship with severity of disease

Author(s):

A Gharavi^,*,

AA Hajagha Mohammadi,

A Ziaee,

MR Sarookhani,

A Javadi,

S Haghazali

Journal of Inflammatory Diseases:Vol. 12, issue 1; 27-34

Published online:Jun 30, 2008

Article type:Research Article

How to Cite:Gharavi A, Hajagha Mohammadi A, Ziaee A, Sarookhani M, Javadi A, et al. Investigation of insulin resistance in patients with liver cirrhosis and its relationship with severity of disease.J Inflamm Dis.2008;12(1):e155374.

Abstract

¯Abstract Background: Insulin resistance and glucose intolerance are commonly associated with liver cirrhosis. Resistance to insulin is an important prognostic factor in liver cirrhosis. Objective: To determine the relationship between insulin resistance and severity of liver cirrhosis. Methods: This was a descriptive-analytic study carried out on 76 patients with stablished liver cirrhosis in Booali hospital (Qazvin) in 2006 and 2007. Their fasting blood sugar, serum insulin level and oral glucose tolerance test (OGTT) were measured. Patients divided into three groups of A, B and C according to the child-pugh classification. Insulin resistance was determined by the homeostasis model assessment (HOMA-IR) in all patients. Data analysis was performed using t test, variance analysis, chi-square and Fishers exact test. Findings: Cirrhosis was found to be strongly associated with insulin resistance (60.5%) and the values obtained for prevalence of insulin resistance for groups A, B, and C of Child-Pugh Classification were %31.6, %66.7 and %74.1, respectively. The relationship between IR and severity of liver cirrhosis was significant, statistically (p=0.01). Diabetes mellitus was diagnosed in 26 subjects (34.2%), impaired glucose tolerance in 24 (31.6%) and normal glucose tolerance in 26 (34.2%) using OGTT. Conclusion: Insulin resistance increased with stage of liver cirrhosis as defined by Child-Pugh score.

Keywords

Keywords: Liver Cirrhosis

Insulin

Insulin Resistance

Liver Function Tests

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 0
Last Update: 1 month ago
Scopus by Title (Ref): 1
Last Update: 1 month ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

A Gharavi:[PubMed][Scholar]
AA Hajagha Mohammadi:[PubMed][Scholar]
A Ziaee:[PubMed][Scholar]
MR Sarookhani:[PubMed][Scholar]
A Javadi:[PubMed][Scholar]
S Haghazali:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

Investigation of insulin resistance in patients with liver cirrhosis and its relationship with severity of disease

Abstract

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 3 days ago