The relationship between serum sialic acid level and some cardiovascular markers in patients with myocardial infarctions

authors:

avatar M Shafie , avatar H Kharrazi , * , avatar T Darabi , avatar A R Moludi

Journal of Inflammatory Diseases: Vol.12, issue 1; 57-61
article type: issue_documents_importer

how to cite: Shafie M, Kharrazi H, Darabi T, Moludi A R. The relationship between serum sialic acid level and some cardiovascular markers in patients with myocardial infarctions. J Inflamm Dis. 2008;12(1):e155379. 

Abstract

¯Abstract Background: Many reports indicate an idiopathic rise in sialic acid level after myocardial infarction (MI). Such reaction attached to its correlation with both reactionary indices in the acute phase and fatty indices has been thoroughly studied and produced controversial findings. Hence, it is considered as an important diagnostic agent. Objective: To study the relationship between serum total sialic acid (TSA) level and several diagnostic markers including lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and troponin in MI patients. Methods: This was a descriptive analytical study in which 30 patients with MI investigated. Blood samples were collected in three consecutive days following the occurrence of MI. Serum levels of TSA, CPK, and LDH were measured using spectrophotometric technique and troponin determination by ELISA. The data were investigated by SPSS using t-test and Pearsons correlation coefficient for further analysis. Findings: The serum levels of TSA and the target markers were considerably higher than recommended normal levels. There was a significant relationship between TSA and troponin (P=0.05, r=0.47) at the first day and TSA and LDH at the second day (P=0.01, r=0.52). Conclusion: Regarding the results found in our study, higher level of TSA together with increase in concentration of several cardiac specific markers including troponin and LDH implies that it could be considered as an early diagnostic marker in cardiovascular diseases