Prevalence of metallo-β-lactamase among imipenem-resistant Acinetobacter spp. isolated from selected hospitals in Karaj (2010)

A Mohebi; S Aghaei; Mohammadzadeh M; M Tavakoli

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Prevalence of metallo-β-lactamase among imipenem-resistant Acinetobacter spp. isolated from selected hospitals in Karaj (2010)

Author(s):

A Mohebi,

S Aghaei,

Mohammadzadeh M^1,*,

M Tavakoli

1Qazvin University of Medical Sciences, Qazvin, Iran

Journal of Inflammatory Diseases:Vol. 16, issue 2; 52-57

Article type:Research Article

How to Cite:A MohebiS AghaeiMohammadzadeh MM TavakoliPrevalence of metallo-β-lactamase among imipenem-resistant Acinetobacter spp. isolated from selected hospitals in Karaj (2010).J Inflamm Dis.16(2):e155696.

Abstract

Background : Imipenem-resistant Acinetobacter spp. resulting from metallo-β-lactamase (MBLs)-producing strains have been reported to be among important causes of nosocomial infections and of serious therapeutic problem worldwide. Objective : To determine the prevalence of metallo-β-lactamase among imipenem-resistant Acinetobacter isolates based on phenotypic methods. Methods : This was an descriptive study in which 140 clinical isolates of Acinetobacter spp. were initially tested for imipenem susceptibility and later for metallo-β-lactamase production using combined disk diffusion, double disk synergy test, and Hodge test during 2010. Antibiotic susceptibility of positive metallo-β-lactamase isolates were further evaluated by disk diffusion technique using CLSI methodology. Findings : Of 140 isolates, 29 (20.7%) were imipenem-resistant Acinetobacter. Positive phonetypic test for metallo-β-lactamase was 24 (17.1%). Conclusion : The result of this study is indicative of growing number of nosocomial infections associated with multidrug-resistant Acinetobacter spp. in this region leading to difficulties in antibiotic therapy.

Keywords

Nosocomial Infections

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