Abstract
Background: Recent studies have shown that the use of prolonged or intermittent normobaric hyperoxia (90 percent) can decrease brain damages caused by stroke. Objective: The aim of this study was to investigate the effects of oxygen radicals in potentiating the blood-brain barrier caused by normobaric hyperoxia in a rat model of stroke. Methods: This was a experimental study performed in spring 2010. A total of 42 male Wistar rats (250-350 g) were initially divided into two main groups. Both group were exposed to normobaric hyperoxia (90 percent HO) and room air (21 percent RA) 4 h/day for 6 days. Later, each main group was subdivided into three subgroups to receive dimethyltiourea. After 24 h, the neurologic deficit scores and blood-brain barrier permeability were assessed. Data were analyzed by one way ANOVA and Mann Whitney U tests. Findings: The medians of neurologic deficit scores and blood-brain barrier permeability decreased in RA and HO (P=0.02). The neurologic deficit score and the reduced brain edema were significantly relived by MT (P=0.43). Conclusion: The blood-brain impermeability caused by intermittent normobaric hyperoxia was relieved by use of oxygen radical scavengers.
Keywords
Neuroprotection Stroke Normobaric Hyperoxia Neurologic Deficit Free Oxygen Radicals
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.