Abstract
Background: Insulin is administered for glycemic control in type 2 diabetic patients with secondary failure to oral antidiabetic drugs . Achieving good glycemic control requires a long time with relatively high insulin dose. Objective: The aim of this study was to compare the effect of treatment with insulin alone versus insulin plus sulfonylurea in type 2 diabetic patients . Methods: In this randomized clinical trial, 45 patients with secondary failure to oral antidiabetic drugs who referred to Bou-Ali hospital during 2009-2010, were randomly allocated into two groups of insulin alone and insulin plus sulfonylurea. Fasting and postprandial blood sugar, insulin dose, and weight gain were measured monthly up to 3 months. Data were analyzed by T-test and Chi-square test. Findings: A t the end of the first and the third month of the treatment, mean fasting blood sugar was 146.3 ±21.1 mg/dl and 126.9±10.2 mg/dl in combination therapy group and was 166.1 ± 28.7 mg/dl and 144.5 ± 20.9 mg/dl in insulin alone group, respectively ( P =0.01 and P=0.001, respectively). Mean postprandial blood sugar in combination group was lower than insulin alone group at the end of the third month (P=0.009). The difference in mean insulin dose between 2 groups was statistically significant at the end of the third month (P<0.001). Conclusion: With regard to the results, combination therapy with insulin plus sulfonylurea versus insulin alone would result in faster improvement of glycemic control and lower daily insulin dose.
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© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.