Relationship between serum vitamin D level and severity of rheumatoid arthritis

mahnaz abbasi; SA Farzam; mahnaz abbasi; A Akbari

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Relationship between serum vitamin D level and severity of rheumatoid arthritis

Author(s):

mahnaz abbasi¹,

SA Farzam¹,

mahnaz abbasi^,*,

A Akbari¹

1assistance professor of qazvin university of medical sciences

Journal of Inflammatory Diseases:Vol. 17, issue 5; 25-31

Article type:Research Article

How to Cite:mahnaz abbasiSA Farzammahnaz abbasiA AkbariRelationship between serum vitamin D level and severity of rheumatoid arthritis.J Inflamm Dis.17(5):e155779.

Abstract

Background: Recent studies have suggested a relation between vitamin D serum level and autoimmune diseases including rheumatoid arthritis (RA). Also, vitamin D has an important role in regulating the immune system. Objective: The present study aimed at exploring the relation between serum level of vitamin D and severity of RA. Methods: The study group consisted of 153 RA patients not on vitamin D supplements who had referred to Qazvin Avicenna Hospital. Disease activity was assessed according to the disease activity score28 (DAS28). Serum levels of vitamin D and Erythrocyte Sedimentation Rate (ESR) were determined for all the participants. Findings: Vitamin D deficiency was found in 105 RA patients (68.6%). Patients were divided into three groups of low, moderate and high disease activity according to DAS28 score with 86 (56.2%), 33 (21.5%) and 34 (22.2%) patients respectively. A significant negative correlation was found between serum level of vitamin D and disease severity according to DAS28. Similarly, a negative correlation was shown to exist between the patients' pain intensity according to VAS score, and their ESR serum level (P

Keywords

Rheumatoid Arthritis

Vitamin D Deficiency

Disease Severity

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